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(−)-Epicatechin Prevents Blood Pressure Increase and Reduces Locomotor Hyperactivity in Young Spontaneously Hypertensive Rats
المؤلفون المشاركون
Kluknavsky, Michal
Muchova, Jana
Radosinska, J.
Berenyiova, A.
Drobna, M.
Lukac, S.
Bernatova, Iveta
Puzserova, Angelika
Balis, Peter
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-03
دولة النشر
مصر
عدد الصفحات
14
التخصصات الرئيسية
الملخص EN
This study investigated the effects of subchronic (−)-epicatechin (Epi) treatment on locomotor activity and hypertension development in young spontaneously hypertensive rats (SHR).
Epi was administered in drinking water (100 mg/kg/day) for 2 weeks.
Epi significantly prevented the development of hypertension (138±2 versus 169±5 mmHg, p<0.001) and reduced total distance traveled in the open-field test (22±2 versus 35±4 m, p<0.01).
In blood, Epi significantly enhanced erythrocyte deformability, increased total antioxidant capacity, and decreased nitrotyrosine concentration.
In the aorta, Epi significantly increased nitric oxide (NO) synthase (NOS) activity and elevated the NO-dependent vasorelaxation.
In the left heart ventricle, Epi increased NOS activity without altering gene expressions of nNOS, iNOS, and eNOS.
Moreover, Epi reduced superoxide production in the left heart ventricle and the aorta.
In the brain, Epi increased nNOS gene expression (in the brainstem and cerebellum) and eNOS expression (in the cerebellum) but had no effect on overall NOS activity.
In conclusion, Epi prevented the development of hypertension and reduced locomotor hyperactivity in young SHR.
These effects resulted from improved cardiovascular NO bioavailability concurrently with increased erythrocyte deformability, without changes in NO production in the brain.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kluknavsky, Michal& Balis, Peter& Puzserova, Angelika& Radosinska, J.& Berenyiova, A.& Drobna, M.…[et al.]. 2016. (−)-Epicatechin Prevents Blood Pressure Increase and Reduces Locomotor Hyperactivity in Young Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114149
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kluknavsky, Michal…[et al.]. (−)-Epicatechin Prevents Blood Pressure Increase and Reduces Locomotor Hyperactivity in Young Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1114149
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kluknavsky, Michal& Balis, Peter& Puzserova, Angelika& Radosinska, J.& Berenyiova, A.& Drobna, M.…[et al.]. (−)-Epicatechin Prevents Blood Pressure Increase and Reduces Locomotor Hyperactivity in Young Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114149
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114149
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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