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(−)-Epicatechin Prevents Blood Pressure Increase and Reduces Locomotor Hyperactivity in Young Spontaneously Hypertensive Rats
Joint Authors
Kluknavsky, Michal
Muchova, Jana
Radosinska, J.
Berenyiova, A.
Drobna, M.
Lukac, S.
Bernatova, Iveta
Puzserova, Angelika
Balis, Peter
Source
Oxidative Medicine and Cellular Longevity
Issue
Vol. 2016, Issue 2016 (31 Dec. 2016), pp.1-14, 14 p.
Publisher
Hindawi Publishing Corporation
Publication Date
2016-11-03
Country of Publication
Egypt
No. of Pages
14
Main Subjects
Abstract EN
This study investigated the effects of subchronic (−)-epicatechin (Epi) treatment on locomotor activity and hypertension development in young spontaneously hypertensive rats (SHR).
Epi was administered in drinking water (100 mg/kg/day) for 2 weeks.
Epi significantly prevented the development of hypertension (138±2 versus 169±5 mmHg, p<0.001) and reduced total distance traveled in the open-field test (22±2 versus 35±4 m, p<0.01).
In blood, Epi significantly enhanced erythrocyte deformability, increased total antioxidant capacity, and decreased nitrotyrosine concentration.
In the aorta, Epi significantly increased nitric oxide (NO) synthase (NOS) activity and elevated the NO-dependent vasorelaxation.
In the left heart ventricle, Epi increased NOS activity without altering gene expressions of nNOS, iNOS, and eNOS.
Moreover, Epi reduced superoxide production in the left heart ventricle and the aorta.
In the brain, Epi increased nNOS gene expression (in the brainstem and cerebellum) and eNOS expression (in the cerebellum) but had no effect on overall NOS activity.
In conclusion, Epi prevented the development of hypertension and reduced locomotor hyperactivity in young SHR.
These effects resulted from improved cardiovascular NO bioavailability concurrently with increased erythrocyte deformability, without changes in NO production in the brain.
American Psychological Association (APA)
Kluknavsky, Michal& Balis, Peter& Puzserova, Angelika& Radosinska, J.& Berenyiova, A.& Drobna, M.…[et al.]. 2016. (−)-Epicatechin Prevents Blood Pressure Increase and Reduces Locomotor Hyperactivity in Young Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114149
Modern Language Association (MLA)
Kluknavsky, Michal…[et al.]. (−)-Epicatechin Prevents Blood Pressure Increase and Reduces Locomotor Hyperactivity in Young Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-14.
https://search.emarefa.net/detail/BIM-1114149
American Medical Association (AMA)
Kluknavsky, Michal& Balis, Peter& Puzserova, Angelika& Radosinska, J.& Berenyiova, A.& Drobna, M.…[et al.]. (−)-Epicatechin Prevents Blood Pressure Increase and Reduces Locomotor Hyperactivity in Young Spontaneously Hypertensive Rats. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1114149
Data Type
Journal Articles
Language
English
Notes
Includes bibliographical references
Record ID
BIM-1114149