Oxidation-Reduction Potential as a Biomarker for Severity and Acute Outcome in Traumatic Brain Injury
المؤلفون المشاركون
Bar-Or, David
Carrick, Matthew M.
Slone, Denetta S.
Bjugstad, Kimberly B.
Rael, Leonard T.
Levy, Stewart
Mains, Charles W.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-25
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
There are few reliable markers for assessing traumatic brain injury (TBI).
Elevated levels of oxidative stress have been observed in TBI patients.
We hypothesized that oxidation-reduction potential (ORP) could be a potent biomarker in TBI.
Two types of ORP were measured in patient plasma samples: the static state of oxidative stress (sORP) and capacity for induced oxidative stress (icORP).
Differences in ORP values as a function of time after injury, severity, and hospital discharge were compared using ANOVAs with significance at p ≤ 0.05 .
Logit regression analyses were used to predict acute outcome comparing ORP, Injury Severity Score (ISS), Abbreviated Injury Scale (AIS), and Glasgow Coma Scale (GCS).
Antioxidant capacity (icORP) on day 4 was prognostic for acute outcomes ( p < 0.05 ).
An odds ratio of 4.08 was associated with poor acute outcome when icORP > 7.25 μC.
IcORP was a better predictor than ISS, AIS, or GCS scores.
sORP increased in those with the highest ISS values ( p < 0.05 ).
Based on these findings ORP is useful biomarker for severity and acute outcome in TBI patients.
Changes in ORP values on day 4 after injury were the most prognostic, suggesting that patients’ response to brain injury over time is a factor that determines outcome.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bjugstad, Kimberly B.& Rael, Leonard T.& Levy, Stewart& Carrick, Matthew M.& Mains, Charles W.& Slone, Denetta S.…[et al.]. 2016. Oxidation-Reduction Potential as a Biomarker for Severity and Acute Outcome in Traumatic Brain Injury. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114157
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bjugstad, Kimberly B.…[et al.]. Oxidation-Reduction Potential as a Biomarker for Severity and Acute Outcome in Traumatic Brain Injury. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114157
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bjugstad, Kimberly B.& Rael, Leonard T.& Levy, Stewart& Carrick, Matthew M.& Mains, Charles W.& Slone, Denetta S.…[et al.]. Oxidation-Reduction Potential as a Biomarker for Severity and Acute Outcome in Traumatic Brain Injury. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114157
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114157
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر