Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3KAktNrf2 Pathway
المؤلفون المشاركون
Liu, Tong-qiang
Yu, Xiao-fang
Ding, Xiao-qiang
Shaopeng, Liu
Nana, Song
Xialian, Xu
Jiachang, Hu
Ting, Zhang
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-13
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Contrast-induced acute renal injury (CI-AKI) has become a common cause of hospital-acquired renal failure.
However, the development of prophylaxis strategies and approved therapies for CI-AKI is limited.
Salvianolic acid B (SB) can treat cardiovascular-related diseases.
The aim of the present study was to assess the effect of SB on prevention of CI-AKI and explore its underlying mechanisms.
We examined its effectiveness of preventing renal injury in a novel CI-AKI rat model.
Compared with saline, intravenous SB pretreatment significantly attenuated elevations in serum creatinine and the histological changes of renal tubular injuries, reduced the number of apoptosis-positive tubular cells, activated Nrf2, and lowered the levels of renal oxidative stress induced by iodinated contrast media.
The above renoprotection of SB was abolished by the PI3K inhibitor (wortmannin).
In HK-2 cells, SB activated Nrf2 and decreased the levels of oxidative stress induced by hydrogen peroxide and subsequently improved cell viability.
The above cytoprotection of SB was blocked by the PI3K inhibitor (wortmannin) or siNrf2.
Thus, our results demonstrate that, due to its antioxidant properties, SB has the potential to effectively prevent CI-AKI via the PI3K/Akt/Nrf2 pathway.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Tong-qiang& Shaopeng, Liu& Yu, Xiao-fang& Nana, Song& Xialian, Xu& Jiachang, Hu…[et al.]. 2016. Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3KAktNrf2 Pathway. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114173
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Tong-qiang…[et al.]. Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3KAktNrf2 Pathway. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1114173
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Tong-qiang& Shaopeng, Liu& Yu, Xiao-fang& Nana, Song& Xialian, Xu& Jiachang, Hu…[et al.]. Salvianolic Acid B Prevents Iodinated Contrast Media-Induced Acute Renal Injury in Rats via the PI3KAktNrf2 Pathway. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1114173
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114173
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر