Resveratrol Reduces the Incidence of Portal Vein System Thrombosis after Splenectomy in a Rat Fibrosis Model
المؤلفون المشاركون
Ma, Zhenhua
Xu, Meng
Xue, Wanli
Bai, Jigang
Wu, Shengli
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-28
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Purpose.
To investigate the preventive effect of resveratrol (RES) on the formation of portal vein system thrombosis (PVST) in a rat fibrosis model.
Methods.
A total of 64 male SD rats, weighing 200–300 g, were divided into five groups: Sham operation, Splenectomy I, Splenectomy II, RES, and low molecular weight heparin (LMWH), with the former two groups as nonfibrosis controls.
Blood samples were subjected to biochemical assays.
Platelet apoptosis was measured by flow cytometry.
All rats were euthanized for PVST detection one week after operation.
Results.
No PVST occurred in nonfibrosis controls.
Compared to Splenectomy II, the incidences of PVST in RES and LMWH groups were significantly decreased (both p < 0.05 ).
Two rats in LMWH group died before euthanasia due to intra-abdominal hemorrhage.
In RES group, significant decreases in platelet aggregation, platelet radical oxygen species (ROS) production, and increase in platelet nitric oxide (NO) synthesis and platelet apoptosis were observed when compared with Splenectomy II (all p < 0.001 ), while in LMWH group only significant decrease in platelet aggregation was observed.
Conclusion.
Prophylactic application of RES could safely reduce the incidence of PVST after splenectomy in cirrhotic rat.
Regulation of platelet function and induction of platelet apoptosis might be the underlying mechanisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Xu, Meng& Xue, Wanli& Ma, Zhenhua& Bai, Jigang& Wu, Shengli. 2016. Resveratrol Reduces the Incidence of Portal Vein System Thrombosis after Splenectomy in a Rat Fibrosis Model. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1114197
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Xu, Meng…[et al.]. Resveratrol Reduces the Incidence of Portal Vein System Thrombosis after Splenectomy in a Rat Fibrosis Model. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1114197
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Xu, Meng& Xue, Wanli& Ma, Zhenhua& Bai, Jigang& Wu, Shengli. Resveratrol Reduces the Incidence of Portal Vein System Thrombosis after Splenectomy in a Rat Fibrosis Model. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1114197
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114197
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر