![](/images/graphics-bg.png)
Protective Effects of Hydrogen Sulfide in the Ageing Kidney
المؤلفون المشاركون
Jin, Sheng
Hou, Cui-Lan
Wang, Ming-Jie
Zhu, Yi-Chun
Sun, Chen
Huang, Yong
Mu, Xue-Pan
Chen, Ying
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-01
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Aims.
The study aimed to examine whether hydrogen sulfide (H2S) generation changed in the kidney of the ageing mouse and its relationship with impaired kidney function.
Results.
H2S levels in the plasma, urine, and kidney decreased significantly in ageing mice.
The expression of two known H2S-producing enzymes in kidney, cystathionine γ-lyase (CSE) and cystathionine-β-synthase (CBS), decreased significantly during ageing.
Chronic H2S donor (NaHS, 50 μmol/kg/day, 10 weeks) treatment could alleviate oxidative stress levels and renal tubular interstitial collagen deposition.
These protective effects may relate to transcription factor Nrf2 activation and antioxidant proteins such as HO-1, SIRT1, SOD1, and SOD2 expression upregulation in the ageing kidney after NaHS treatment.
Furthermore, the expression of H2S-producing enzymes changed with exogenous H2S administration and contributed to elevated H2S levels in the ageing kidney.
Conclusions.
Endogenous hydrogen sulfide production in the ageing kidney is insufficient.
Exogenous H2S can partially rescue ageing-related kidney dysfunction by reducing oxidative stress, decreasing collagen deposition, and enhancing Nrf2 nuclear translocation.
Recovery of endogenous hydrogen sulfide production may also contribute to the beneficial effects of NaHS treatment.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Hou, Cui-Lan& Wang, Ming-Jie& Sun, Chen& Huang, Yong& Jin, Sheng& Mu, Xue-Pan…[et al.]. 2016. Protective Effects of Hydrogen Sulfide in the Ageing Kidney. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114212
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Hou, Cui-Lan…[et al.]. Protective Effects of Hydrogen Sulfide in the Ageing Kidney. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1114212
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Hou, Cui-Lan& Wang, Ming-Jie& Sun, Chen& Huang, Yong& Jin, Sheng& Mu, Xue-Pan…[et al.]. Protective Effects of Hydrogen Sulfide in the Ageing Kidney. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114212
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114212
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
![](/images/ebook-kashef.png)
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
![](/images/kashef-image.png)