The Role of Mitochondria and OxidativeAntioxidative Imbalance in Pathobiology of Chronic Obstructive Pulmonary Disease
المؤلفون المشاركون
Górski, Paweł
Sitarek, Przemysław
Białas, Adam Jerzy
Miłkowska-Dymanowska, Joanna
Piotrowski, Wojciech Jerzy
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-15، 15ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-26
دولة النشر
مصر
عدد الصفحات
15
التخصصات الرئيسية
الملخص EN
Chronic obstructive pulmonary disease (COPD) is a common preventable and treatable disease, characterized by persistent airflow limitation that is usually progressive and associated with an enhanced chronic inflammatory response in the airways and the lung to noxious particles or gases.
The major risk factor of COPD, which has been proven in many studies, is the exposure to cigarette smoke.
However, it is 15–20% of all smokers who develop COPD.
This is why we should recognize the pathobiology of COPD as involving a complex interaction between several factors, including genetic vulnerability.
Oxidant-antioxidant imbalance is recognized as one of the significant factors in COPD pathogenesis.
Numerous exogenous and endogenous sources of ROS are present in pathobiology of COPD.
One of endogenous sources of ROS is mitochondria.
Although leakage of electrons from electron transport chain and forming of ROS are the effect of physiological functioning of mitochondria, there are various intra- and extracellular factors which may increase this amount and significantly contribute to oxidative-antioxidative imbalance.
With the coexistence with impaired antioxidant defence, all these issues lead to oxidative and carbonyl stress.
Both of these states play a significant role in pathobiology of COPD and may account for development of major comorbidities of this disease.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Białas, Adam Jerzy& Sitarek, Przemysław& Miłkowska-Dymanowska, Joanna& Piotrowski, Wojciech Jerzy& Górski, Paweł. 2016. The Role of Mitochondria and OxidativeAntioxidative Imbalance in Pathobiology of Chronic Obstructive Pulmonary Disease. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1114238
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Białas, Adam Jerzy…[et al.]. The Role of Mitochondria and OxidativeAntioxidative Imbalance in Pathobiology of Chronic Obstructive Pulmonary Disease. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-15.
https://search.emarefa.net/detail/BIM-1114238
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Białas, Adam Jerzy& Sitarek, Przemysław& Miłkowska-Dymanowska, Joanna& Piotrowski, Wojciech Jerzy& Górski, Paweł. The Role of Mitochondria and OxidativeAntioxidative Imbalance in Pathobiology of Chronic Obstructive Pulmonary Disease. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-15.
https://search.emarefa.net/detail/BIM-1114238
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114238
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر