Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1
المؤلفون المشاركون
Bartosch, Birke
Smirnova, Olga A.
Ivanova, Olga N.
Valuev-Elliston, Vladimir T.
Mukhtarov, Furkat
Kochetkov, Sergey N.
Ivanov, Alexander V.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-20
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Replication of hepatitis C virus (HCV) is associated with the induction of oxidative stress, which is thought to play a major role in various liver pathologies associated with chronic hepatitis C.
NS5A protein of the virus is one of the two key viral proteins that are known to trigger production of reactive oxygen species (ROS).
To date it has been considered that NS5A induces oxidative stress by altering calcium homeostasis.
Herein we show that NS5A-induced oxidative stress was only moderately inhibited by the intracellular calcium chelator BAPTA-AM and not at all inhibited by the drug that blocks the Ca2+ flux from ER to mitochondria.
Furthermore, ROS production was not accompanied by induction of ER oxidoreductins (Ero1), H2O2-producing enzymes that are implicated in the regulation of calcium fluxes.
Instead, we found that NS5A contributes to ROS production by activating expression of NADPH oxidases 1 and 4 as well as cytochrome P450 2E1.
These effects were mediated by domain I of NS5A protein.
NOX1 and NOX4 induction was mediated by enhanced production of transforming growth factor β1 (TGFβ1).
Thus, our data show that NS5A protein induces oxidative stress by several multistep mechanisms.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Smirnova, Olga A.& Ivanova, Olga N.& Bartosch, Birke& Valuev-Elliston, Vladimir T.& Mukhtarov, Furkat& Kochetkov, Sergey N.…[et al.]. 2016. Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114333
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Smirnova, Olga A.…[et al.]. Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1114333
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Smirnova, Olga A.& Ivanova, Olga N.& Bartosch, Birke& Valuev-Elliston, Vladimir T.& Mukhtarov, Furkat& Kochetkov, Sergey N.…[et al.]. Hepatitis C Virus NS5A Protein Triggers Oxidative Stress by Inducing NADPH Oxidases 1 and 4 and Cytochrome P450 2E1. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1114333
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114333
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر