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Assessment of Mitochondrial Dysfunction and Monoamine Oxidase Contribution to Oxidative Stress in Human Diabetic Hearts
المؤلفون المشاركون
Duicu, Oana M.
Lighezan, Rodica
Sturza, Adrian
Ceausu, Raluca A.
Borza, Claudia
Vaduva, Adrian
Noveanu, Lavinia
Gaspar, Marian
Ionac, Adina
Feier, Horea
Muntean, Danina M.
Mornos, Cristian
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-13
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Mitochondria-related oxidative stress is a pathomechanism causally linked to coronary heart disease (CHD) and diabetes mellitus (DM).
Recently, mitochondrial monoamine oxidases (MAOs) have emerged as novel sources of oxidative stress in the cardiovascular system and experimental diabetes.
The present study was purported to assess the mitochondrial impairment and the contribution of MAOs-related oxidative stress to the cardiovascular dysfunction in coronary patients with/without DM.
Right atrial appendages were obtained from 75 patients randomized into 3 groups: (1) Control (CTRL), valvular patients without CHD; (2) CHD, patients with confirmed CHD; and (3) CHD-DM, patients with CHD and DM.
Mitochondrial respiration was measured by high-resolution respirometry and MAOs expression was evaluated by RT-PCR and immunohistochemistry.
Hydrogen peroxide (H2O2) emission was assessed by confocal microscopy and spectrophotometrically.
The impairment of mitochondrial respiration was substrate-independent in CHD-DM group.
MAOs expression was comparable among the groups, with the predominance of MAO-B isoform but no significant differences regarding oxidative stress were detected by either method.
Incubation of atrial samples with MAOs inhibitors significantly reduced the H2O2 in all groups.
In conclusion, abnormal mitochondrial respiration occurs in CHD and is more severe in DM and MAOs contribute to oxidative stress in human diseased hearts with/without DM.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Duicu, Oana M.& Lighezan, Rodica& Sturza, Adrian& Ceausu, Raluca A.& Vaduva, Adrian& Feier, Horea…[et al.]. 2016. Assessment of Mitochondrial Dysfunction and Monoamine Oxidase Contribution to Oxidative Stress in Human Diabetic Hearts. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114367
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Duicu, Oana M.…[et al.]. Assessment of Mitochondrial Dysfunction and Monoamine Oxidase Contribution to Oxidative Stress in Human Diabetic Hearts. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1114367
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Duicu, Oana M.& Lighezan, Rodica& Sturza, Adrian& Ceausu, Raluca A.& Vaduva, Adrian& Feier, Horea…[et al.]. Assessment of Mitochondrial Dysfunction and Monoamine Oxidase Contribution to Oxidative Stress in Human Diabetic Hearts. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114367
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114367
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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