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Impact of Antioxidants on Cardiolipin Oxidation in Liposomes: Why Mitochondrial Cardiolipin Serves as an Apoptotic Signal?
المؤلفون المشاركون
Lokhmatikov, Alexey V.
Voskoboynikova, Natalia
Cherepanov, Dmitry A.
Skulachev, Maxim V.
Steinhoff, Heinz-Jürgen
Skulachev, Vladimir P.
Mulkidjanian, Armen Y.
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-19، 19ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-26
دولة النشر
مصر
عدد الصفحات
19
التخصصات الرئيسية
الملخص EN
Molecules of mitochondrial cardiolipin (CL) get selectively oxidized upon oxidative stress, which triggers the intrinsic apoptotic pathway.
In a chemical model most closely resembling the mitochondrial membrane—liposomes of pure bovine heart CL—we compared ubiquinol-10, ubiquinol-6, and alpha-tocopherol, the most widespread naturally occurring antioxidants, with man-made, quinol-based amphiphilic antioxidants.
Lipid peroxidation was induced by addition of an azo initiator in the absence and presence of diverse antioxidants, respectively.
The kinetics of CL oxidation was monitored via formation of conjugated dienes at 234 nm.
We found that natural ubiquinols and ubiquinol-based amphiphilic antioxidants were equally efficient in protecting CL liposomes from peroxidation; the chromanol-based antioxidants, including alpha-tocopherol, were 2-3 times less efficient.
Amphiphilic antioxidants, but not natural ubiquinols and alpha-tocopherol, were able, additionally, to protect the CL bilayer from oxidation by acting from the water phase.
We suggest that the previously reported therapeutic efficiency of mitochondrially targeted amphiphilic antioxidants is owing to their ability to protect those CL molecules that are inaccessible to natural hydrophobic antioxidants, being trapped within respiratory supercomplexes.
The high susceptibility of such occluded CL molecules to oxidation may have prompted their recruitment as apoptotic signaling molecules by nature.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lokhmatikov, Alexey V.& Voskoboynikova, Natalia& Cherepanov, Dmitry A.& Skulachev, Maxim V.& Steinhoff, Heinz-Jürgen& Skulachev, Vladimir P.…[et al.]. 2016. Impact of Antioxidants on Cardiolipin Oxidation in Liposomes: Why Mitochondrial Cardiolipin Serves as an Apoptotic Signal?. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1114420
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lokhmatikov, Alexey V.…[et al.]. Impact of Antioxidants on Cardiolipin Oxidation in Liposomes: Why Mitochondrial Cardiolipin Serves as an Apoptotic Signal?. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-19.
https://search.emarefa.net/detail/BIM-1114420
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lokhmatikov, Alexey V.& Voskoboynikova, Natalia& Cherepanov, Dmitry A.& Skulachev, Maxim V.& Steinhoff, Heinz-Jürgen& Skulachev, Vladimir P.…[et al.]. Impact of Antioxidants on Cardiolipin Oxidation in Liposomes: Why Mitochondrial Cardiolipin Serves as an Apoptotic Signal?. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-19.
https://search.emarefa.net/detail/BIM-1114420
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114420
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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