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Beneficial Effects of Physical Exercise on Functional Capacity and Skeletal Muscle Oxidative Stress in Rats with Aortic Stenosis-Induced Heart Failure
المؤلفون المشاركون
Laurindo, Francisco R. M.
Fernandes, Ana Angélica Henrique
Campos, D. H. S.
Cezar, M. D. M.
Okoshi, K.
Gomes, Mariana Janini
Martinez, Paula Felippe
Pagan, Luana Urbano
Bonomo, Camila
Lima, Aline Regina Ruiz
Damatto, Ricardo Luiz
Damatto, Felipe Cezar
Rosa, Camila Moreno
Garcia, Camila Marchiolli
Reyes, David Rafael Abreu
Fernandes, Denise Castro
Okoshi, Marina Politi
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-20
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Objective.
We evaluated the influence of exercise on functional capacity, cardiac remodeling, and skeletal muscle oxidative stress, MAPK, and NF-κB pathway in rats with aortic stenosis- (AS-) induced heart failure (HF).
Methods and Results.
Eighteen weeks after AS induction, rats were assigned into sedentary control (C-Sed), exercised control (C-Ex), sedentary AS (AS-Sed), and exercised AS (AS-Ex) groups.
Exercise was performed on treadmill for eight weeks.
Statistical analyses were performed with Goodman and ANOVA or Mann-Whitney.
HF features frequency and mortality did not differ between AS groups.
Exercise improved functional capacity, assessed by maximal exercise test on treadmill, without changing echocardiographic parameters.
Soleus cross-sectional areas did not differ between groups.
Lipid hydroperoxide concentration was higher in AS-Sed than C-Sed and AS-Ex.
Activity of antioxidant enzymes superoxide dismutase and glutathione peroxidase was changed in AS-Sed and restored in AS-Ex.
NADPH oxidase activity and gene expression of its subunits did not differ between AS groups.
Total ROS generation was lower in AS-Ex than C-Ex.
Exercise modulated MAPK in AS-Ex and did not change NF-κB pathway proteins.
Conclusion.
Exercise improves functional capacity in rats with AS-induced HF regardless of echocardiographic parameter changes.
In soleus, exercise reduces oxidative stress, preserves antioxidant enzyme activity, and modulates MAPK expression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Gomes, Mariana Janini& Martinez, Paula Felippe& Campos, D. H. S.& Pagan, Luana Urbano& Bonomo, Camila& Lima, Aline Regina Ruiz…[et al.]. 2016. Beneficial Effects of Physical Exercise on Functional Capacity and Skeletal Muscle Oxidative Stress in Rats with Aortic Stenosis-Induced Heart Failure. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114431
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Gomes, Mariana Janini…[et al.]. Beneficial Effects of Physical Exercise on Functional Capacity and Skeletal Muscle Oxidative Stress in Rats with Aortic Stenosis-Induced Heart Failure. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1114431
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Gomes, Mariana Janini& Martinez, Paula Felippe& Campos, D. H. S.& Pagan, Luana Urbano& Bonomo, Camila& Lima, Aline Regina Ruiz…[et al.]. Beneficial Effects of Physical Exercise on Functional Capacity and Skeletal Muscle Oxidative Stress in Rats with Aortic Stenosis-Induced Heart Failure. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114431
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114431
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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