Hepatoprotective Effect of Quercetin on Endoplasmic Reticulum Stress and Inflammation after Intense Exercise in Mice through Phosphoinositide 3-Kinase and Nuclear Factor-Kappa B
المؤلفون المشاركون
Liu, Liegang
Yao, Ping
Li, Yanyan
Xu, Yanyan
Tang, Yuhan
Li, Juan
Gao, Chao
Yu, Xiao
Wang, Jing
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-18
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
The mechanisms underlying intense exercise-induced liver damage and its potential treatments remain unclear.
We explored the hepatoprotection and mechanisms of quercetin, a naturally occurring flavonoid, in strenuous exercise-derived endoplasmic reticulum stress (ERS) and inflammation.
Intense exercise (28 m/min at a 5° slope for 90 min) resulted in the leakage of aminotransferases in the BALB/C mice.
The hepatic ultrastructural malformations and oxidative stress levels were attenuated by quercetin (100 mg/kg·bw).
Intense exercise and thapsigargin- (Tg-) induced ERS (glucose-regulated protein 78, GRP78) and inflammatory cytokines levels (IL-6 and TNF-α) were decreased with quercetin.
Furthermore, quercetin resulted in phosphoinositide 3-kinase (PI3K) induction, Ca2+ restoration, and blockade of the activities of Jun N-terminal kinase (JNK), activating transcription factor 6 (ATF6) and especially NF-κB (p65 and p50 nuclear translocation).
A PI3K inhibitor abrogated the protection of quercetin on ERS and inflammation of mouse hepatocytes.
SP600125 (JNK inhibitor), AEBSF (ATF6 inhibitor), and especially PDTC (NF-κB inhibitor) enhanced the quercetin-induced protection against Tg stimulation.
Collectively, intense exercise-induced ERS and inflammation were attenuated by quercetin.
PI3K/Akt activation and JNK, ATF6, and especially NF-κB suppression were involved in the protection.
Our results highlight a novel preventive strategy for treating ERS and inflammation-mediated liver damage induced by intense exercise using natural phytochemicals.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Tang, Yuhan& Li, Juan& Gao, Chao& Xu, Yanyan& Li, Yanyan& Yu, Xiao…[et al.]. 2016. Hepatoprotective Effect of Quercetin on Endoplasmic Reticulum Stress and Inflammation after Intense Exercise in Mice through Phosphoinositide 3-Kinase and Nuclear Factor-Kappa B. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114437
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Tang, Yuhan…[et al.]. Hepatoprotective Effect of Quercetin on Endoplasmic Reticulum Stress and Inflammation after Intense Exercise in Mice through Phosphoinositide 3-Kinase and Nuclear Factor-Kappa B. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1114437
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Tang, Yuhan& Li, Juan& Gao, Chao& Xu, Yanyan& Li, Yanyan& Yu, Xiao…[et al.]. Hepatoprotective Effect of Quercetin on Endoplasmic Reticulum Stress and Inflammation after Intense Exercise in Mice through Phosphoinositide 3-Kinase and Nuclear Factor-Kappa B. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114437
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114437
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر