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Effects of Bauhinia forficata Tea on Oxidative Stress and Liver Damage in Diabetic Mice
المؤلفون المشاركون
Franco, Jeferson Luis
Posser, Thaís
Zemolin, A. P. P.
Mendez, Andreas S. L.
Salgueiro, Andréia Caroline Fernandes
Folmer, Vanderlei
da Silva, Marianne Pires
Puntel, Robson Luiz
Puntel, Gustavo Orione
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-29
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
This study was designed to evaluate the effects of Bauhinia forficata Link subsp.
pruinosa (BF) tea on oxidative stress and liver damage in streptozotocin (STZ)-induced diabetic mice.
Diabetic male mice have remained 30 days without any treatment.
BF treatment started on day 31 and continued for 21 days as a drinking-water substitute.
We evaluated (1) BF chemical composition; (2) glucose levels; (3) liver/body weight ratio and liver transaminases; (4) reactive oxygen species (ROS), lipid peroxidation, and protein carbonylation in liver; (5) superoxide dismutase (SOD) and catalase (CAT) activities in liver; (6) δ-aminolevulinate dehydratase (δ-ALA-D) and nonprotein thiols (NPSH) in liver; (7) Nrf2, NQO-1, and HSP70 levels in liver and pancreas.
Phytochemical analyses identified four phenols compounds.
Diabetic mice present high levels of NQO-1 in pancreas, increased levels of ROS and lipid peroxidation in liver, and decrease in CAT activity.
BF treatment normalized all these parameters.
BF did not normalize hyperglycemia, liver/body weight ratio, aspartate aminotransferase, protein carbonyl, NPSH levels, and δ-ALA-D activity.
The raised oxidative stress seems to be a potential mechanism involved in liver damage in hyperglycemic conditions.
Our results indicated that BF protective effect could be attributed to its antioxidant capacity, more than a hypoglycemic potential.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Salgueiro, Andréia Caroline Fernandes& Folmer, Vanderlei& da Silva, Marianne Pires& Mendez, Andreas S. L.& Zemolin, A. P. P.& Posser, Thaís…[et al.]. 2015. Effects of Bauhinia forficata Tea on Oxidative Stress and Liver Damage in Diabetic Mice. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114461
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Salgueiro, Andréia Caroline Fernandes…[et al.]. Effects of Bauhinia forficata Tea on Oxidative Stress and Liver Damage in Diabetic Mice. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114461
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Salgueiro, Andréia Caroline Fernandes& Folmer, Vanderlei& da Silva, Marianne Pires& Mendez, Andreas S. L.& Zemolin, A. P. P.& Posser, Thaís…[et al.]. Effects of Bauhinia forficata Tea on Oxidative Stress and Liver Damage in Diabetic Mice. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114461
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114461
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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