Functional Epithelium Remodeling in Response to Applied Stress under In Vitro Conditions
المؤلفون المشاركون
Pajic-Lijakovic, Ivana
Milivojevic, Milan
المصدر
Applied Bionics and Biomechanics
العدد
المجلد 2019، العدد 2019 (31 ديسمبر/كانون الأول 2019)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2019-05-19
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Mathematical modeling is often used in tissue engineering in order to overcome one of its major challenges: transformation of complex biological and rheological behaviors of cells and tissue in a mathematically predictive and physically manipulative engineering process.
The successive accomplishment of this task will greatly help in quantifying and optimizing clinical application of the tissue engineering products.
One of the problems emerging in this area is the relation between resting and migrating cell groups, as well as between different configurations of migrating cells and viscoelasticity.
A deeper comprehension of the relation between various configurations of migrating cells and viscoelasticity at the supracellular level represents the prerequisite for optimization of the performance of the artificial epithelium.
Since resting and migrating cell groups have a considerable difference in stiffness, a change in their mutual volume ratio and distribution may affect the viscoelasticity of multicellular surfaces.
If those cell groups are treated as different phases, then an analogous model may be applied to represent such systems.
In this work, a two-step Eyring model is developed in order to demonstrate the main mechanical and biochemical factors that influence configurations of migrating cells.
This model could be also used for considering the long-time cell rearrangement under various types of applied stress.
The results of this theoretical analysis point out the cause-consequence relationship between the configuration of migrating cells and rheological behavior of multicellular surfaces.
Configuration of migrating cells is influenced by mechanical and biochemical perturbations, difficult to measure experimentally, which lead to uncorrelated motility.
Uncorrelated motility results in (1) decrease of the volume fraction of migrating cells, (2) change of their configuration, and (3) softening of multicellular surfaces.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Pajic-Lijakovic, Ivana& Milivojevic, Milan. 2019. Functional Epithelium Remodeling in Response to Applied Stress under In Vitro Conditions. Applied Bionics and Biomechanics،Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1114623
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Pajic-Lijakovic, Ivana& Milivojevic, Milan. Functional Epithelium Remodeling in Response to Applied Stress under In Vitro Conditions. Applied Bionics and Biomechanics No. 2019 (2019), pp.1-13.
https://search.emarefa.net/detail/BIM-1114623
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Pajic-Lijakovic, Ivana& Milivojevic, Milan. Functional Epithelium Remodeling in Response to Applied Stress under In Vitro Conditions. Applied Bionics and Biomechanics. 2019. Vol. 2019, no. 2019, pp.1-13.
https://search.emarefa.net/detail/BIM-1114623
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114623
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر