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Toll-Like Receptor 4 Reduces Oxidative Injury via Glutathione Activity in Sheep
المؤلفون المشاركون
Deng, Shoulong
Yu, Kun
Zhang, Baolu
Liu, Guoshi
Liu, Yixun
Lian, Zhengxing
Wu, Qian
Li, Yan
Zhang, Xiaosheng
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Toll-like receptor 4 (TLR4) is an important sensor of Gram-negative bacteria and can trigger activation of the innate immune system.
Increased activation of TLR4 can lead to the induction of oxidative stress.
Herein, the pathway whereby TLR4 affects antioxidant activity was studied.
In TLR4-overexpressing sheep, TLR4 expression was found to be related to the integration copy number when monocytes were challenged with lipopolysaccharide (LPS).
Consequently, production of malondialdehyde (MDA) was increased, which could increase the activation of prooxidative stress enzymes.
Meanwhile, activation of an antioxidative enzyme, glutathione peroxidase (GSH-Px), was increased.
Real-time PCR showed that expression of activating protein-1 (AP-1) and the antioxidative-related genes was increased.
By contrast, the expression levels of superoxide dismutase 1 (SOD1) and catalase (CAT) were reduced.
In transgenic sheep, glutathione (GSH) levels were dramatically reduced.
Furthermore, transgenic sheep were intradermally injected with LPS in each ear.
The amounts of inflammatory infiltrates were correlated with the number of TLR4 copies that were integrated in the genome.
Additionally, the translation of γ-glutamylcysteine synthetase (γ-GCS) was increased.
Our findings indicated that overexpression of TLR4 in sheep could ameliorate oxidative injury through GSH secretion that was induced by LPS stimulation.
Furthermore, TLR4 promoted γ-GCS translation through the AP-1 pathway, which was essential for GSH synthesis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Deng, Shoulong& Yu, Kun& Wu, Qian& Li, Yan& Zhang, Xiaosheng& Zhang, Baolu…[et al.]. 2015. Toll-Like Receptor 4 Reduces Oxidative Injury via Glutathione Activity in Sheep. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114710
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Deng, Shoulong…[et al.]. Toll-Like Receptor 4 Reduces Oxidative Injury via Glutathione Activity in Sheep. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1114710
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Deng, Shoulong& Yu, Kun& Wu, Qian& Li, Yan& Zhang, Xiaosheng& Zhang, Baolu…[et al.]. Toll-Like Receptor 4 Reduces Oxidative Injury via Glutathione Activity in Sheep. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1114710
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114710
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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