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Role of Galectin-3 in Obesity and Impaired Glucose Homeostasis
المؤلفون المشاركون
Menini, Stefano
Iacobini, Carla
Blasetti Fantauzzi, Claudia
Pesce, Carlo M.
Pugliese, Giuseppe
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-06
دولة النشر
مصر
عدد الصفحات
7
التخصصات الرئيسية
الملخص EN
Galectin-3 is an important modulator of several biological functions.
It has been implicated in numerous disease conditions, particularly in the long-term complications of diabetes because of its ability to bind the advanced glycation/lipoxidation end products that accumulate in target organs and exert their toxic effects by triggering proinflammatory and prooxidant pathways.
Recent evidence suggests that galectin-3 may also participate in the development of obesity and type 2 diabetes.
It has been shown that galectin-3 levels are higher in obese and diabetic individuals and parallel deterioration of glucose homeostasis.
Two studies in galectin-3 knockout mice fed a high-fat diet (HFD) have shown increased adiposity and adipose tissue and systemic inflammation associated with altered glucose homeostasis, suggesting that galectin-3 negatively modulates the responsiveness of innate and adaptive immunity to overnutrition.
However, these studies have also shown that impaired glucose homeostasis occurs in galectin-3 knockout animals independently of obesity.
Moreover, another study reported decreased weight and fat mass in HFD-fed galectin-3 knockout mice.
In vitro, galectin-3 was found to stimulate differentiation of preadipocytes into mature adipocytes.
Altogether, these data indicate that galectin-3 deserves further attention in order to clarify its role as a potential player and therapeutic target in obesity and type 2 diabetes.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Menini, Stefano& Iacobini, Carla& Blasetti Fantauzzi, Claudia& Pesce, Carlo M.& Pugliese, Giuseppe. 2015. Role of Galectin-3 in Obesity and Impaired Glucose Homeostasis. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1114793
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Menini, Stefano…[et al.]. Role of Galectin-3 in Obesity and Impaired Glucose Homeostasis. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-7.
https://search.emarefa.net/detail/BIM-1114793
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Menini, Stefano& Iacobini, Carla& Blasetti Fantauzzi, Claudia& Pesce, Carlo M.& Pugliese, Giuseppe. Role of Galectin-3 in Obesity and Impaired Glucose Homeostasis. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1114793
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114793
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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