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Downregulation of Glutathione Biosynthesis Contributes to Oxidative Stress and Liver Dysfunction in Acute Kidney Injury
المؤلفون المشاركون
Shang, Yue
Siow, Yaw L.
Isaak, Cara K.
O, Karmin
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-10-30
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Ischemia-reperfusion is a common cause for acute kidney injury and can lead to distant organ dysfunction.
Glutathione is a major endogenous antioxidant and its depletion directly correlates to ischemia-reperfusion injury.
The liver has high capacity for producing glutathione and is a key organ in modulating local and systemic redox balance.
In the present study, we investigated the mechanism by which kidney ischemia-reperfusion led to glutathione depletion and oxidative stress.
The left kidney of Sprague-Dawley rats was subjected to 45 min ischemia followed by 6 h reperfusion.
Ischemia-reperfusion impaired kidney and liver function.
This was accompanied by a decrease in glutathione levels in the liver and plasma and increased hepatic lipid peroxidation and plasma homocysteine levels.
Ischemia-reperfusion caused a significant decrease in mRNA and protein levels of hepatic glutamate-cysteine ligase mediated through the inhibition of transcription factor Nrf2.
Ischemia-reperfusion inhibited hepatic expression of cystathionine γ-lyase, an enzyme responsible for producing cysteine (an essential precursor for glutathione synthesis) through the transsulfuration pathway.
These results suggest that inhibition of glutamate-cysteine ligase expression and downregulation of the transsulfuration pathway lead to reduced hepatic glutathione biosynthesis and elevation of plasma homocysteine levels, which, in turn, may contribute to oxidative stress and distant organ injury during renal ischemia-reperfusion.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Shang, Yue& Siow, Yaw L.& Isaak, Cara K.& O, Karmin. 2016. Downregulation of Glutathione Biosynthesis Contributes to Oxidative Stress and Liver Dysfunction in Acute Kidney Injury. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114806
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Shang, Yue…[et al.]. Downregulation of Glutathione Biosynthesis Contributes to Oxidative Stress and Liver Dysfunction in Acute Kidney Injury. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1114806
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Shang, Yue& Siow, Yaw L.& Isaak, Cara K.& O, Karmin. Downregulation of Glutathione Biosynthesis Contributes to Oxidative Stress and Liver Dysfunction in Acute Kidney Injury. Oxidative Medicine and Cellular Longevity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1114806
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114806
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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