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Potential Modulation of Sirtuins by Oxidative Stress
المؤلفون المشاركون
Santos, Leonardo
Escande, Carlos
Denicola, Ana
المصدر
Oxidative Medicine and Cellular Longevity
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-14
دولة النشر
مصر
عدد الصفحات
12
التخصصات الرئيسية
الملخص EN
Sirtuins are a conserved family of NAD-dependent protein deacylases.
Initially proposed as histone deacetylases, it is now known that they act on a variety of proteins including transcription factors and metabolic enzymes, having a key role in the regulation of cellular homeostasis.
Seven isoforms are identified in mammals (SIRT1–7), all of them sharing a conserved catalytic core and showing differential subcellular localization and activities.
Oxidative stress can affect the activity of sirtuins at different levels: expression, posttranslational modifications, protein-protein interactions, and NAD levels.
Mild oxidative stress induces the expression of sirtuins as a compensatory mechanism, while harsh or prolonged oxidant conditions result in dysfunctional modified sirtuins more prone to degradation by the proteasome.
Oxidative posttranslational modifications have been identified in vitro and in vivo, in particular cysteine oxidation and tyrosine nitration.
In addition, oxidative stress can alter the interaction with other proteins, like SIRT1 with its protein inhibitor DBC1 resulting in a net increase of deacetylase activity.
In the same way, manipulation of cellular NAD levels by pharmacological inhibition of other NAD-consuming enzymes results in activation of SIRT1 and protection against obesity-related pathologies.
Nevertheless, further research is needed to establish the molecular mechanisms of redox regulation of sirtuins to further design adequate pharmacological interventions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Santos, Leonardo& Escande, Carlos& Denicola, Ana. 2015. Potential Modulation of Sirtuins by Oxidative Stress. Oxidative Medicine and Cellular Longevity،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114853
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Santos, Leonardo…[et al.]. Potential Modulation of Sirtuins by Oxidative Stress. Oxidative Medicine and Cellular Longevity No. 2016 (2016), pp.1-12.
https://search.emarefa.net/detail/BIM-1114853
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Santos, Leonardo& Escande, Carlos& Denicola, Ana. Potential Modulation of Sirtuins by Oxidative Stress. Oxidative Medicine and Cellular Longevity. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1114853
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1114853
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
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