Abnormal Echogenicity of the Substantia Nigra, Raphe Nuclei, and Third-Ventricle Width as Markers of Cognitive Impairment in Parkinsonian Disorders: A Cross-Sectional Study
المؤلفون المشاركون
Bouwmans, Angela E. P.
Leentjens, Albert F. G.
Mess, Werner H.
Weber, Wim E. J.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-10
دولة النشر
مصر
عدد الصفحات
9
التخصصات الرئيسية
الملخص EN
Background.
Patients with Parkinson’s disease (PD) have a high risk of cognitive problems.
Objective.
This study assesses whether abnormal echogenicity of the substantia nigra (SN) and raphe nuclei (RN) and the diameter of third ventricle are markers of cognitive impairment in patients with PD and other forms of parkinsonism.
Methods.
126 outpatients with early signs of parkinsonism underwent transcranial sonography (TCS).
The scales for the outcome of Parkinson’s disease cognition (SCOPA-COG) were used as cognitive measure.
Definite neurological diagnosis was established after two-year follow-up.
Results.
One-third of the patients with PD and half of those with APS had signs of cognitive impairment.
The echogenicity of the SN was not related to cognitive impairment.
The diameter of the third ventricle was significantly larger in PD patients with cognitive impairment compared to those without.
In patients with APS we found a significantly higher frequency of hypoechogenic RN in patients with cognitive problems.
Conclusions.
Cognitive impairment is already present in a substantial proportion of patients with PD and APS at first referral.
In patients with APS the frequency of hypoechogenic RN points to the direction of other pathophysiology with more emphasis on deficits in the serotonergic neurotransmitter system.
The larger diameter of the third ventricle in PD patients with cognitive impairment may reflect Alzheimer like brain atrophy, as has been reported in earlier studies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bouwmans, Angela E. P.& Leentjens, Albert F. G.& Mess, Werner H.& Weber, Wim E. J.. 2016. Abnormal Echogenicity of the Substantia Nigra, Raphe Nuclei, and Third-Ventricle Width as Markers of Cognitive Impairment in Parkinsonian Disorders: A Cross-Sectional Study. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115235
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bouwmans, Angela E. P.…[et al.]. Abnormal Echogenicity of the Substantia Nigra, Raphe Nuclei, and Third-Ventricle Width as Markers of Cognitive Impairment in Parkinsonian Disorders: A Cross-Sectional Study. Parkinson’s Disease No. 2016 (2016), pp.1-9.
https://search.emarefa.net/detail/BIM-1115235
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bouwmans, Angela E. P.& Leentjens, Albert F. G.& Mess, Werner H.& Weber, Wim E. J.. Abnormal Echogenicity of the Substantia Nigra, Raphe Nuclei, and Third-Ventricle Width as Markers of Cognitive Impairment in Parkinsonian Disorders: A Cross-Sectional Study. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115235
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115235
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر