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Gastrointestinal Dysfunctions in Parkinson’s Disease: Symptoms and Treatments
المؤلفون المشاركون
Poirier, Andrée-Anne
Aubé, Benoit
Côté, Mélissa
Morin, Nicolas
Di Paolo, Thérèse
Soulet, Denis
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-23، 23ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-12-06
دولة النشر
مصر
عدد الصفحات
23
التخصصات الرئيسية
الملخص EN
A diagnosis of Parkinson’s disease is classically established after the manifestation of motor symptoms such as rigidity, bradykinesia, and tremor.
However, a growing body of evidence supports the hypothesis that nonmotor symptoms, especially gastrointestinal dysfunctions, could be considered as early biomarkers since they are ubiquitously found among confirmed patients and occur much earlier than their motor manifestations.
According to Braak’s hypothesis, the disease is postulated to originate in the intestine and then spread to the brain via the vagus nerve, a phenomenon that would involve other neuronal types than the well-established dopaminergic population.
It has therefore been proposed that peripheral nondopaminergic impairments might precede the alteration of dopaminergic neurons in the central nervous system and, ultimately, the emergence of motor symptoms.
Considering the growing interest in the gut-brain axis in Parkinson’s disease, this review aims at providing a comprehensive picture of the multiple gastrointestinal features of the disease, along with the therapeutic approaches used to reduce their burden.
Moreover, we highlight the importance of gastrointestinal symptoms with respect to the patients’ responses towards medical treatments and discuss the various possible adverse interactions that can potentially occur, which are still poorly understood.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Poirier, Andrée-Anne& Aubé, Benoit& Côté, Mélissa& Morin, Nicolas& Di Paolo, Thérèse& Soulet, Denis. 2016. Gastrointestinal Dysfunctions in Parkinson’s Disease: Symptoms and Treatments. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-23.
https://search.emarefa.net/detail/BIM-1115257
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Poirier, Andrée-Anne…[et al.]. Gastrointestinal Dysfunctions in Parkinson’s Disease: Symptoms and Treatments. Parkinson’s Disease No. 2016 (2016), pp.1-23.
https://search.emarefa.net/detail/BIM-1115257
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Poirier, Andrée-Anne& Aubé, Benoit& Côté, Mélissa& Morin, Nicolas& Di Paolo, Thérèse& Soulet, Denis. Gastrointestinal Dysfunctions in Parkinson’s Disease: Symptoms and Treatments. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-23.
https://search.emarefa.net/detail/BIM-1115257
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115257
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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