Association Analysis of NALCN Polymorphisms rs1338041 and rs61973742 in a Chinese Population with Isolated Cervical Dystonia
المؤلفون المشاركون
Song, Wei
Cao, Bei
Yang, Jing
Shang, Hui-Fang
Zhou, Qingqing
Chen, Yongping
Wei, Qianqian
Ou, Ruwei
Zhao, Bi
Wu, Ying
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-28
دولة النشر
مصر
عدد الصفحات
6
التخصصات الرئيسية
الملخص EN
Background.
A genome-wide association study (GWAS) demonstrated a possible association between cervical dystonia (CD) and a sodium leak channel, nonselective (NALCN) gene.
However, the association between NALCN and CD was largely unknown in Asian population.
The present study was carried out to examine the associations between the two single nucleotide polymorphisms (SNPs) rs1338041 and rs61973742 in the NALCN gene and CD in a Chinese population.
Methods.
In a cohort of 201 patients with isolated CD, we genotyped the two SNPs rs1338041 and rs61973742 using polymerase chain reaction restriction fragment length polymorphism (PCR-RFLP).
We also included 289 unrelated, age- and sex-matched healthy controls (HCs) from the same region.
Result.
No significant differences were observed in either the genotype distributions or the minor allele frequencies (MAFs) of the two SNPs between the CD patients and the HCs.
There were no significant differences between early-onset and late-onset CD patients, between patients with and without a positive family history of dystonia, or between patients with and without tremor or sensory tricks.
Conclusion.
Lack of association between the SNPs of NALCN and CD suggests that the SNPs of NALCN do not play a role in CD in a Chinese population.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Zhou, Qingqing& Yang, Jing& Cao, Bei& Chen, Yongping& Wei, Qianqian& Ou, Ruwei…[et al.]. 2016. Association Analysis of NALCN Polymorphisms rs1338041 and rs61973742 in a Chinese Population with Isolated Cervical Dystonia. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1115278
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Zhou, Qingqing…[et al.]. Association Analysis of NALCN Polymorphisms rs1338041 and rs61973742 in a Chinese Population with Isolated Cervical Dystonia. Parkinson’s Disease No. 2016 (2016), pp.1-6.
https://search.emarefa.net/detail/BIM-1115278
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Zhou, Qingqing& Yang, Jing& Cao, Bei& Chen, Yongping& Wei, Qianqian& Ou, Ruwei…[et al.]. Association Analysis of NALCN Polymorphisms rs1338041 and rs61973742 in a Chinese Population with Isolated Cervical Dystonia. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1115278
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115278
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر