Pathophysiology of Motor Dysfunction in Parkinson’s Disease as the Rationale for Drug Treatment and Rehabilitation
المؤلفون المشاركون
Smania, Nicola
Magrinelli, Francesca
Federico, Angela
Tocco, Pierluigi
Roncari, Laura
Tamburin, Stefano
Picelli, Alessandro
Zanette, Giampietro
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-18، 18ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-06-06
دولة النشر
مصر
عدد الصفحات
18
التخصصات الرئيسية
الملخص EN
Cardinal motor features of Parkinson’s disease (PD) include bradykinesia, rest tremor, and rigidity, which appear in the early stages of the disease and largely depend on dopaminergic nigrostriatal denervation.
Intermediate and advanced PD stages are characterized by motor fluctuations and dyskinesia, which depend on complex mechanisms secondary to severe nigrostriatal loss and to the problems related to oral levodopa absorption, and motor and nonmotor symptoms and signs that are secondary to marked dopaminergic loss and multisystem neurodegeneration with damage to nondopaminergic pathways.
Nondopaminergic dysfunction results in motor problems, including posture, balance and gait disturbances, and fatigue, and nonmotor problems, encompassing depression, apathy, cognitive impairment, sleep disturbances, pain, and autonomic dysfunction.
There are a number of symptomatic drugs for PD motor signs, but the pharmacological resources for nonmotor signs and symptoms are limited, and rehabilitation may contribute to their treatment.
The present review will focus on classical notions and recent insights into the neuropathology, neuropharmacology, and neurophysiology of motor dysfunction of PD.
These pieces of information represent the basis for the pharmacological, neurosurgical, and rehabilitative approaches to PD.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Magrinelli, Francesca& Picelli, Alessandro& Tocco, Pierluigi& Federico, Angela& Roncari, Laura& Smania, Nicola…[et al.]. 2016. Pathophysiology of Motor Dysfunction in Parkinson’s Disease as the Rationale for Drug Treatment and Rehabilitation. Parkinson’s Disease،Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1115287
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Magrinelli, Francesca…[et al.]. Pathophysiology of Motor Dysfunction in Parkinson’s Disease as the Rationale for Drug Treatment and Rehabilitation. Parkinson’s Disease No. 2016 (2016), pp.1-18.
https://search.emarefa.net/detail/BIM-1115287
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Magrinelli, Francesca& Picelli, Alessandro& Tocco, Pierluigi& Federico, Angela& Roncari, Laura& Smania, Nicola…[et al.]. Pathophysiology of Motor Dysfunction in Parkinson’s Disease as the Rationale for Drug Treatment and Rehabilitation. Parkinson’s Disease. 2016. Vol. 2016, no. 2016, pp.1-18.
https://search.emarefa.net/detail/BIM-1115287
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115287
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر