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Treating Chronic Pain with SSRIs: What Do We Know?
المؤلفون المشاركون
Patetsos, Elias
Horjales-Araujo, Emilia
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-03
دولة النشر
مصر
عدد الصفحات
17
التخصصات الرئيسية
الملخص EN
Serotonin is a monoamine neurotransmitter that plays a major role in both nociception and mood regulation.
Alterations in the 5-hydroxytryptophan (5HT) system have been reported in chronic pain patients.
In recent years, Selective Serotonin Reuptake Inhibitors (SSRIs) have been suggested as an alternative treatment for chronic pain due to the fact that they are better tolerated presenting less secondary effects than other antidepressants such as tricyclic antidepressants.
Although several clinical trials have been published, the effectiveness of SSRI as treatment for pain conditions is inconclusive.
This review aims to summarise what is known, regarding the effectiveness of SSRI as a treatment for chronic pain conditions in adults.
A total of 36 studies involving a total of 1898 participants were included in this review.
Of the 36 trials included in the review, 2 used zimelidine as treatment, 3 used escitalopram, 4 used fluvoxamine, 4 used sertraline, 6 used citalopram, 8 used paroxetine, 9 used fluoxetine, and one used both citalopram and paroxetine.
Because the trials included in this review are quite heterogeneous, only qualitative analyses were performed.
SSRI seems to have an effect on most of chronic pain conditions; however, further clinical trials with good methodology leading to low risk of bias are needed in order to conclude once and for all the effect of this drug class as treatment for chronic pain conditions.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Patetsos, Elias& Horjales-Araujo, Emilia. 2016. Treating Chronic Pain with SSRIs: What Do We Know?. Pain Research and Management،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1115401
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Patetsos, Elias& Horjales-Araujo, Emilia. Treating Chronic Pain with SSRIs: What Do We Know?. Pain Research and Management No. 2016 (2016), pp.1-17.
https://search.emarefa.net/detail/BIM-1115401
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Patetsos, Elias& Horjales-Araujo, Emilia. Treating Chronic Pain with SSRIs: What Do We Know?. Pain Research and Management. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1115401
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115401
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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