Diagnostic value of antibodies to citrulline containing peptides in patients with rheumatoid arthritis in southern Iraq
المؤلفون المشاركون
Barakat, Ali M.
Husni, Hasan J.
Mezal, Thurayya J.
al-Khafaji, Adnan Taan
المصدر
العدد
المجلد 15، العدد 1 (31 مارس/آذار 2009)8ص.
الناشر
تاريخ النشر
2009-03-31
دولة النشر
العراق
عدد الصفحات
8
التخصصات الرئيسية
الموضوعات
الملخص EN
A serological study has been done in Al-Nassiriyha, southern Iraq, from December 2006 to August 2007 designed to determine the frequency of anti-cyclic citrullinated peptide antibody (anti-CCP) in a group of patients with rheumatoid arthritis for specific period of time compared with other rheumatic diseases and healthy controls.
Also to show the diagnostic value of anti-CCP antibody in relation to other markers [rheumatoid factor (RF), antinuclear factor (ANF), C-reactive protein (CRP) and cytokines such as interleukin–6 (IL-6), tumor necrosis factor–? (TNF-α)] to discriminate between those patients with and without RA. Blood samples were taken from 121 patients with rheumatoid arthritis, 88 patients of other rheumatic diseases from AL-Hussein Teaching Hospital in AL-Nassiriyah and 120 healthy controls from medical personnel and school students who were healthy.
All the information was taken from the patients and controls. An Enzyme-linked immunosorbent assay was used for estimation of anti-CCP, IL-6, TNF-α and slide agglutination test for the estimation of RF, CRP and ANF.
The seropositivity to anti-CCP in RA patients group was 61.2% among them 23% with low levels of anti-CCP, 25% with moderate levels and 51.3% with high levels (> 60 units /ml.).The high levels of anti-CCP persist for long durations up to 10 years (54.7%).
However, anti-CCP was rarely detected among non- RA rheumatic diseases and healthy controls (2.3% and 2.5% respectively).
Anti-CCP showed the greater specificity (97.6%) and sensitivity (61.2%) compared to the other marker used in this study.
The overall agreement between the tested parameters in their ability to detect RA patient was higher for anti-CCP combined to IL-6 (91.7%) in comparison to the effect of other markers combination.
Although anti-CCP was more common in RA patient with 2-10 years duration of illness, anti-CCP, IL-6 and TNF-α positivity as estimated by ELISA were persistently with high titers regardless the duration of illness.
The majority of RA patients with high anti-CCP levels were among stage three of clinical RA.
Smoking has a positive relation to the increased levels of all tested parameters compared to the non-smokers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Barakat, Ali M.& Husni, Hasan J.& al-Khafaji, Adnan Taan& Mezal, Thurayya J.. 2009. Diagnostic value of antibodies to citrulline containing peptides in patients with rheumatoid arthritis in southern Iraq. Basrah Journal of Surgery،Vol. 15, no. 1.
https://search.emarefa.net/detail/BIM-111541
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Husni, Hasan J.…[et al.]. Diagnostic value of antibodies to citrulline containing peptides in patients with rheumatoid arthritis in southern Iraq. Basrah Journal of Surgery Vol. 15, no. 1 (Mar. 2009).
https://search.emarefa.net/detail/BIM-111541
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Barakat, Ali M.& Husni, Hasan J.& al-Khafaji, Adnan Taan& Mezal, Thurayya J.. Diagnostic value of antibodies to citrulline containing peptides in patients with rheumatoid arthritis in southern Iraq. Basrah Journal of Surgery. 2009. Vol. 15, no. 1.
https://search.emarefa.net/detail/BIM-111541
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-111541
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر