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miR-125b and miR-100 Are Predictive Biomarkers of Response to Induction Chemotherapy in Osteosarcoma
المؤلفون المشاركون
Kondo, Tadashi
Takeshita, Fumitaka
Kosaka, Nobuyoshi
Arai, Yasuhito
Qiao, Zhiwei
Kubota, Daisuke
Ochiya, Takahiro
Fujiwara, Tomohiro
Yoshida, Akihiko
Kawai, Akira
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-21
دولة النشر
مصر
عدد الصفحات
11
التخصصات الرئيسية
الملخص EN
Osteosarcoma is the most common primary malignancy in bone.
Patients who respond poorly to induction chemotherapy are at higher risk of adverse prognosis.
The molecular basis for such poor prognosis remains unclear.
We investigated miRNA expression in eight open biopsy samples to identify miRNAs predictive of response to induction chemotherapy and thus maybe used for risk stratification therapy.
The samples were obtained from four patients with inferior necrosis (Huvos I/II) and four patients with superior necrosis (Huvos III/IV) following induction chemotherapy.
We found six miRNAs, including miR-125b and miR-100, that were differentially expressed > 2-fold ( p < 0.05 ) in patients who respond poorly to treatment.
The association between poor prognosis and the abundance of miR-125b and miR-100 was confirmed by quantitative reverse transcriptase-polymerase chain reaction in 20 additional osteosarcoma patients.
Accordingly, overexpression of miR-125b and miR-100 in three osteosarcoma cell lines enhanced cell proliferation, invasiveness, and resistance to chemotherapeutic drugs such as methotrexate, doxorubicin, and cisplatin.
In addition, overexpression of miR-125b blocked the ability of these chemotherapy agents to induce apoptosis.
As open biopsy is routinely performed to diagnose osteosarcoma, levels of miR-125b and miR-100 in these samples may be used as basis for risk stratification therapy.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kubota, Daisuke& Kosaka, Nobuyoshi& Fujiwara, Tomohiro& Yoshida, Akihiko& Arai, Yasuhito& Qiao, Zhiwei…[et al.]. 2016. miR-125b and miR-100 Are Predictive Biomarkers of Response to Induction Chemotherapy in Osteosarcoma. Complexity،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1115741
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kubota, Daisuke…[et al.]. miR-125b and miR-100 Are Predictive Biomarkers of Response to Induction Chemotherapy in Osteosarcoma. Complexity No. 2016 (2016), pp.1-11.
https://search.emarefa.net/detail/BIM-1115741
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kubota, Daisuke& Kosaka, Nobuyoshi& Fujiwara, Tomohiro& Yoshida, Akihiko& Arai, Yasuhito& Qiao, Zhiwei…[et al.]. miR-125b and miR-100 Are Predictive Biomarkers of Response to Induction Chemotherapy in Osteosarcoma. Complexity. 2016. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1115741
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115741
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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