A Systematic Literature Review of Adverse Events Associated with Systemic Treatments Used in Advanced Soft Tissue Sarcoma
المؤلفون المشاركون
Oglesby, A.
Kaye, James A.
Colosia, Ann
Khan, Shahnaz
Hackshaw, Michelle D.
Skolnik, Jeffrey M.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-19
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
This systematic literature review describes adverse events (AEs) among patients with soft tissue sarcoma (STS) who received second-line or later anticancer therapies.
Searches were conducted in PubMed, EMBASE, and Cochrane Central Register of Controlled Trials for studies of adults with advanced or metastatic STS who received systemic anticancer therapy before enrollment in a randomized-controlled trial of pazopanib, another targeted cancer agent, or cytotoxic chemotherapy.
Of 204 publications identified, seven articles representing six unique studies met inclusion criteria.
Additional safety results for pazopanib were identified on ClinicalTrials.gov.
Hematologic toxicities were common with all therapies evaluated (pazopanib, trabectedin, dacarbazine ± gemcitabine, gemcitabine ± docetaxel, cyclophosphamide, and ifosfamide).
Studies differed in AE type, timing of assessment, and outcomes reported, although patient populations and AE assessment timing were relatively similar for pazopanib and trabectedin.
AEs that were more common with trabectedin than pazopanib were anemia, neutropenia, nausea/vomiting, and elevations in aspartate aminotransferase and alanine aminotransferase.
An AE that was more common with pazopanib than trabectedin was anorexia.
Only the pazopanib study reported AE frequencies versus placebo.
A planned meta-analysis was not feasible, as there was no common comparator.
More well-designed studies that include common comparators are needed for comparison of safety effects among treatments for STS.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Colosia, Ann& Khan, Shahnaz& Hackshaw, Michelle D.& Oglesby, A.& Kaye, James A.& Skolnik, Jeffrey M.. 2016. A Systematic Literature Review of Adverse Events Associated with Systemic Treatments Used in Advanced Soft Tissue Sarcoma. Complexity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1115759
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Colosia, Ann…[et al.]. A Systematic Literature Review of Adverse Events Associated with Systemic Treatments Used in Advanced Soft Tissue Sarcoma. Complexity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1115759
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Colosia, Ann& Khan, Shahnaz& Hackshaw, Michelle D.& Oglesby, A.& Kaye, James A.& Skolnik, Jeffrey M.. A Systematic Literature Review of Adverse Events Associated with Systemic Treatments Used in Advanced Soft Tissue Sarcoma. Complexity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1115759
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115759
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر