HIV-1 Evolutionary Patterns Associated with Metastatic Kaposi’s Sarcoma during AIDS
المؤلفون المشاركون
Lamers, Susanna L.
Rose, Rebecca
Nolan, David J.
Fogel, Gary B.
Barbier, Andrew E.
Salemi, Marco
McGrath, Michael S.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-29
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Kaposi’s sarcoma (KS) in HIV-infected individuals can have a wide range of clinical outcomes, from indolent skin tumors to a life-threatening visceral cancer.
KS tumors contain endothelial-related cells and inflammatory cells that may be HIV-infected.
In this study we tested if HIV evolutionary patterns distinguish KS tumor relatedness and progression.
Multisite autopsies from participants who died from HIV-AIDS with KS prior to the availability of antiretroviral therapy were identified at the AIDS and Cancer Specimen Resource (ACSR).
Two patients (KS1 and KS2) died predominantly from non-KS-associated disease and KS3 died due to aggressive and metastatic KS within one month of diagnosis.
Skin and visceral tumor and nontumor autopsy tissues were obtained ( n = 12 ).
Single genome sequencing was used to amplify HIV RNA and DNA, which was present in all tumors.
Independent HIV tumor clades in phylogenies differentiated KS1 and KS2 from KS3, whose sequences were interrelated by both phylogeny and selection.
HIV compartmentalization was confirmed in KS1 and KS2 tumors; however, in KS3, no compartmentalization was observed among sampled tissues.
While the sample size is small, the HIV evolutionary patterns observed in all patients suggest an interplay between tumor cells and HIV-infected cells which provides a selective advantage and could promote KS progression.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Lamers, Susanna L.& Rose, Rebecca& Nolan, David J.& Fogel, Gary B.& Barbier, Andrew E.& Salemi, Marco…[et al.]. 2016. HIV-1 Evolutionary Patterns Associated with Metastatic Kaposi’s Sarcoma during AIDS. Complexity،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1115765
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Lamers, Susanna L.…[et al.]. HIV-1 Evolutionary Patterns Associated with Metastatic Kaposi’s Sarcoma during AIDS. Complexity No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1115765
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Lamers, Susanna L.& Rose, Rebecca& Nolan, David J.& Fogel, Gary B.& Barbier, Andrew E.& Salemi, Marco…[et al.]. HIV-1 Evolutionary Patterns Associated with Metastatic Kaposi’s Sarcoma during AIDS. Complexity. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1115765
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115765
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر