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Endosialin and Associated Protein Expression in Soft Tissue Sarcomas: A Potential Target for Anti-Endosialin Therapeutic Strategies
المؤلفون المشاركون
O’Shannessy, Daniel J.
Dai, Hongyue
Mitchell, Melissa
Huntsman, Shane
Brantley, Stephen
Fenstermacher, David
Reed, Damon R.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-27
دولة النشر
مصر
عدد الصفحات
13
التخصصات الرئيسية
الملخص EN
Endosialin (CD248, TEM-1) is expressed in pericytes, tumor vasculature, tumor fibroblasts, and some tumor cells, including sarcomas, with limited normal tissue expression, and appears to play a key role in tumor-stromal interactions, including angiogenesis.
Monoclonal antibodies targeting endosialin have entered clinical trials, including soft tissue sarcomas.
We evaluated a cohort of 94 soft tissue sarcoma samples to assess the correlation between gene expression and protein expression by immunohistochemistry for endosialin and PDGFR-β, a reported interacting protein, across available diagnoses.
Correlations between the expression of endosialin and 13 other genes of interest were also examined.
Within cohorts of soft tissue diagnoses assembled by tissue type (liposarcoma, leiomyosarcoma, undifferentiated sarcoma, and other), endosialin expression was significantly correlated with a better outcome.
Endosialin expression was highest in liposarcomas and lowest in leiomyosarcomas.
A robust correlation between protein and gene expression data for both endosialin and PDGFR-β was observed.
Endosialin expression positively correlated with PDGFR-β and heparin sulphate proteoglycan 2 and negatively correlated with carbonic anhydrase IX.
Endosialin likely interacts with a network of extracellular and hypoxia activated proteins in sarcomas and other tumor types.
Since expression does vary across histologic groups, endosialin may represent a selective target in soft tissue sarcomas.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
O’Shannessy, Daniel J.& Dai, Hongyue& Mitchell, Melissa& Huntsman, Shane& Brantley, Stephen& Fenstermacher, David…[et al.]. 2016. Endosialin and Associated Protein Expression in Soft Tissue Sarcomas: A Potential Target for Anti-Endosialin Therapeutic Strategies. Complexity،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1115773
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
O’Shannessy, Daniel J.…[et al.]. Endosialin and Associated Protein Expression in Soft Tissue Sarcomas: A Potential Target for Anti-Endosialin Therapeutic Strategies. Complexity No. 2016 (2016), pp.1-13.
https://search.emarefa.net/detail/BIM-1115773
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
O’Shannessy, Daniel J.& Dai, Hongyue& Mitchell, Melissa& Huntsman, Shane& Brantley, Stephen& Fenstermacher, David…[et al.]. Endosialin and Associated Protein Expression in Soft Tissue Sarcomas: A Potential Target for Anti-Endosialin Therapeutic Strategies. Complexity. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1115773
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115773
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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