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Influence of Antipsychotic and Anticholinergic Loads on Cognitive Functions in Patients with Schizophrenia
المؤلفون المشاركون
Rehse, Michael
Bartolovic, Marina
Baum, Katlehn
Richter, Dagmar
Weisbrod, Matthias
Roesch-Ely, Daniela
المصدر
Schizophrenia Research and Treatment
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2016)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-10
دولة النشر
مصر
عدد الصفحات
10
التخصصات الرئيسية
الملخص EN
Many patients with schizophrenia show cognitive impairment.
There is evidence that, beyond a certain dose of antipsychotic medication, the antipsychotic daily dose (ADD) may impair cognitive performance.
Parallel to their D2 receptor antagonism, many antipsychotics show a significant binding affinity to cholinergic muscarinic receptors.
Pharmacological treatment with a high anticholinergic daily dose (CDD) significantly impairs attention and memory performance.
To examine the relationships between individual cognitive performance and ADD and/or CDD, we conducted a retrospective record-based analysis of a sample of n=104 in patients with a diagnosis of schizophrenia, all of whom had completed a comprehensive neuropsychological test battery.
To calculate the individual ADD and CDD, the medication at the time of testing was converted according to equivalence models.
After extracting five principal cognitive components, we examined the impact of ADD and CDD on cognitive performance in the medicated sample and subgroups using multiple regression analysis.
Finally, locally weighted scatterplot smoothing (Loess) was applied to further explore the course of cognitive performance under increasing dosage.
Results showed significant negative effects of ADD on performance in tests of information processing speed and verbal memory.
No effects were found for CDD.
The potential neuropsychopharmacological and clinical implications are discussed.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Rehse, Michael& Bartolovic, Marina& Baum, Katlehn& Richter, Dagmar& Weisbrod, Matthias& Roesch-Ely, Daniela. 2016. Influence of Antipsychotic and Anticholinergic Loads on Cognitive Functions in Patients with Schizophrenia. Schizophrenia Research and Treatment،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1115823
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Rehse, Michael…[et al.]. Influence of Antipsychotic and Anticholinergic Loads on Cognitive Functions in Patients with Schizophrenia. Schizophrenia Research and Treatment No. 2016 (2016), pp.1-10.
https://search.emarefa.net/detail/BIM-1115823
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Rehse, Michael& Bartolovic, Marina& Baum, Katlehn& Richter, Dagmar& Weisbrod, Matthias& Roesch-Ely, Daniela. Influence of Antipsychotic and Anticholinergic Loads on Cognitive Functions in Patients with Schizophrenia. Schizophrenia Research and Treatment. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1115823
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115823
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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