Novel Strategies for the Improvement of Stem Cells’ Transplantation in Degenerative Retinal Diseases
المؤلفون المشاركون
Astilean, Simion
Nicoară, Simona Delia
Potara, Monica
Tudoran, Oana
Șușman, Sergiu
Bărbos, Otilia
Cherecheș, Gabriela
Sorițău, Olga
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-9، 9ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-05-18
دولة النشر
مصر
عدد الصفحات
9
الملخص EN
Currently, there is no cure for the permanent vision loss caused by degenerative retinal diseases.
One of the novel therapeutic strategies aims at the development of stem cells (SCs) based neuroprotective and regenerative medicine.
The main sources of SCs for the treatment of retinal diseases are the embryo, the bone marrow, the region of neuronal genesis, and the eye.
The success of transplantation depends on the origin of cells, the route of administration, the local microenvironment, and the proper combinative formula of growth factors.
The feasibility of SCs based therapies for degenerative retinal diseases was proved in the preclinical setting.
However, their translation into the clinical realm is limited by various factors: the immunogenicity of the cells, the stability of the cell phenotype, the predilection of SCs to form tumors in situ, the abnormality of the microenvironment, and the association of a synaptic rewiring.
To improve SCs based therapies, nanotechnology offers a smart delivery system for biomolecules, such as growth factors for SCs implantation and differentiation into retinal progenitors.
This review explores the main advances in the field of retinal transplantology and applications of nanotechnology in the treatment of retinal diseases, discusses the challenges, and suggests new therapeutic approaches in retinal transplantation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Nicoară, Simona Delia& Șușman, Sergiu& Tudoran, Oana& Bărbos, Otilia& Cherecheș, Gabriela& Astilean, Simion…[et al.]. 2016. Novel Strategies for the Improvement of Stem Cells’ Transplantation in Degenerative Retinal Diseases. Stem Cells International،Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115976
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Nicoară, Simona Delia…[et al.]. Novel Strategies for the Improvement of Stem Cells’ Transplantation in Degenerative Retinal Diseases. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-9.
https://search.emarefa.net/detail/BIM-1115976
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Nicoară, Simona Delia& Șușman, Sergiu& Tudoran, Oana& Bărbos, Otilia& Cherecheș, Gabriela& Astilean, Simion…[et al.]. Novel Strategies for the Improvement of Stem Cells’ Transplantation in Degenerative Retinal Diseases. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-9.
https://search.emarefa.net/detail/BIM-1115976
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1115976
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر