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The Establishment and Characteristics of Rat Model of Atherosclerosis Induced by Hyperuricemia
المؤلفون المشاركون
Ren, Wei
Liu, Zhen
Chen, Tong
Niu, Haitao
Li, Xinde
Cui, Lingling
Li, Changgui
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-21
دولة النشر
مصر
عدد الصفحات
7
الملخص EN
Epidemiological studies have identified hyperuricemia as an independent risk factor for cardiovascular disease.
However, the mechanism whereby hyperuricemia causes atherosclerosis remains unclear.
The objective of the study was to establish a new rat model of hyperuricemia-induced atherosclerosis.
Wistar-Kyoto rats were randomly allocated to either a normal diet (ND), high-fat diet (HFD), or high-adenine diet (HAD), followed by sacrifice 4, 8, or 12 weeks later.
Serum uric acid and lipid levels were analyzed, pathologic changes in the aorta were observed by hematoxylin and eosin staining, and mRNA expression was evaluated by quantitative real-time polymerase chain reaction.
Serum uric acid and TC were significantly increased in the HAD group at 4 weeks compared with the ND group, but there was no significant difference in serum uric acid between the ND and HFD groups.
Aorta calcification occurred earlier and was more severe in the HAD group, compared with the HFD group.
Proliferating cell nuclear antigen, monocyte chemotactic factor-1, intercellular adhesion molecule-1, and vascular cell adhesion molecule-1 mRNA levels were increased in the HFD and HAD groups compared with the ND group.
This new animal model will be a useful tool for investigating the mechanisms responsible for hyperuricemia-induced atherosclerosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Zhen& Chen, Tong& Niu, Haitao& Ren, Wei& Li, Xinde& Cui, Lingling…[et al.]. 2015. The Establishment and Characteristics of Rat Model of Atherosclerosis Induced by Hyperuricemia. Stem Cells International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1116019
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Zhen…[et al.]. The Establishment and Characteristics of Rat Model of Atherosclerosis Induced by Hyperuricemia. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1116019
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Zhen& Chen, Tong& Niu, Haitao& Ren, Wei& Li, Xinde& Cui, Lingling…[et al.]. The Establishment and Characteristics of Rat Model of Atherosclerosis Induced by Hyperuricemia. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1116019
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116019
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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