Mesenchymal Stem Cell Treatment for Steroid RefractoryGraft-versus-Host Disease in Children: A Pilot and First Study from Turkey
المؤلفون المشاركون
Akçay, Arzu
Erbey, Fatih
Atay, Didem
Ovali, Ercument
Ozturk, Gulyuz
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-6، 6ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-13
دولة النشر
مصر
عدد الصفحات
6
الملخص EN
This study evaluated the efficacy of mesenchymal stem cells (MSCs) from bone marrow of a third-party donor for refractory aGVHD.
We report the first experience using MSCs to treat refractory aGVHD in 33 pediatric patients undergoing allogeneic HSCT from Turkey.
Totally, 68 doses of bone marrow derived MSCs were infused.
The median dose of MSC was 1.18×106 cells per kg body weight.
Overall, complete response (CR) was documented in 18 patients, partial response (PR) was documented in 7 patients, and no response (NR) was documented in 8 patients.
The 2-year estimated probability of overall survival (OS) for patients achieving CR and PR/NR was 63.8% and 29.4%, respectively p=0.0002.
While the cumulative incidence of transplant related mortality (TRM) at day 100 after first MSC infusion was 46.6% in PR/NR patients, there was no any TRM at day 100 after first MSC infusion in CR patients p=0.001.
Twelve patients developed chronic GVHD (cGVHD); eight of them were alive, with five having extensive disease and three having limited disease.
In conclusion, MSCs appear to be safe and effective treatment option for pediatric patients with steroid refractory aGVHD.
But the efficacy of MSCs on cGVHD in aGVHD patients treated with MSCs seems to be limited.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Erbey, Fatih& Atay, Didem& Akçay, Arzu& Ovali, Ercument& Ozturk, Gulyuz. 2015. Mesenchymal Stem Cell Treatment for Steroid RefractoryGraft-versus-Host Disease in Children: A Pilot and First Study from Turkey. Stem Cells International،Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1116080
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Erbey, Fatih…[et al.]. Mesenchymal Stem Cell Treatment for Steroid RefractoryGraft-versus-Host Disease in Children: A Pilot and First Study from Turkey. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-6.
https://search.emarefa.net/detail/BIM-1116080
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Erbey, Fatih& Atay, Didem& Akçay, Arzu& Ovali, Ercument& Ozturk, Gulyuz. Mesenchymal Stem Cell Treatment for Steroid RefractoryGraft-versus-Host Disease in Children: A Pilot and First Study from Turkey. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-6.
https://search.emarefa.net/detail/BIM-1116080
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116080
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر