Cancer Stem Cell Signaling during Repopulation in Head and Neck Cancer
المؤلفون المشاركون
Huang, Jiayi
Pruetz, Barbara L.
Thibodeau, Bryan J.
Fortier, Laura E.
Galoforo, Sandra
Baschnagel, Andrew M.
Akervall, Jan
Wilson, George D.
Marples, Brian
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-06
دولة النشر
مصر
عدد الصفحات
10
الملخص EN
The aim of the study was to investigate cancer stem signaling during the repopulation response of a head and neck squamous cell cancer (HNSCC) xenograft after radiation treatment.
Xenografts were generated from low passage HNSCC cells and were treated with either sham radiation or 15 Gy in one fraction.
At different time points, days 0, 3, and 10 for controls and days 4, 7, 12, and 21, after irradiation, 3 tumors per group were harvested for global gene expression, pathway analysis, and immunohistochemical evaluation.
316 genes were identified that were associated with a series of stem cell-related genes and were differentially expressed ( p ≤ 0.01 and 1.5-fold) at a minimum of one time point in UT-SCC-14 xenografts after radiation.
The largest network of genes that showed significant changes after irradiation was associated with CD44, NOTCH1, and MET.
c-MET and ALDH1A3 staining correlated with the changes in gene expression.
A clear pattern emerged that was consistent with the growth inhibition data in that genes associated with stem cell pathways were most active at day 7 and day 12 after irradiation.
The MET/CD44 axis seemed to be an important component of the repopulation response.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wilson, George D.& Thibodeau, Bryan J.& Fortier, Laura E.& Pruetz, Barbara L.& Galoforo, Sandra& Marples, Brian…[et al.]. 2016. Cancer Stem Cell Signaling during Repopulation in Head and Neck Cancer. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116148
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wilson, George D.…[et al.]. Cancer Stem Cell Signaling during Repopulation in Head and Neck Cancer. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1116148
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wilson, George D.& Thibodeau, Bryan J.& Fortier, Laura E.& Pruetz, Barbara L.& Galoforo, Sandra& Marples, Brian…[et al.]. Cancer Stem Cell Signaling during Repopulation in Head and Neck Cancer. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116148
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116148
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر