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Semaphorin 3A Shifts Adipose Mesenchymal Stem Cells towards Osteogenic Phenotype and Promotes Bone Regeneration In Vivo
المؤلفون المشاركون
Zhou, Xue-Ying
Liu, Xiangwei
Tan, Naiwen
Zhou, Yuchao
Chen, Hui
Wei, Hongbo
Chen, Ji
Xu, Xiaoru
Zhang, Sijia
Yang, Guodong
Song, Yingliang
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-09-19
دولة النشر
مصر
عدد الصفحات
13
الملخص EN
Adipose mesenchymal stem cells (ASCs) are considered as the promising seed cells for bone regeneration.
However, the lower osteogenic differentiation capacity limits its therapeutic efficacy.
Identification of the key molecules governing the differences between ASCs and BMSCs would shed light on manipulation of ASCs towards osteogenic phenotype.
In this study, we screened semaphorin family members in ASCs and BMSCs and identified Sema3A as an osteogenic semaphorin that was significantly and predominantly expressed in BMSCs.
The analyses in vitro showed that the overexpression of Sema3A in ASCs significantly enhanced the expression of bone-related genes and extracellular matrix calcium deposition, while decreasing the expression of adipose-related genes and thus lipid droplet formation, resembling a BMSCs phenotype.
Furthermore, Sema3A modified ASCs were then engrafted into poly(lactic-co-glycolic acid) (PLGA) scaffolds to repair the critical-sized calvarial defects in rat model.
As expected, Sema3A modified ASCs encapsulation significantly promoted new bone formation with higher bone volume fraction and bone mineral density.
Additionally, Sema3A was found to simultaneously increase multiple Wnt related genes and thus activating Wnt pathway.
Taken together, our study here identifies Sema3A as a critical gene for osteogenic phenotype and reveals that Sema3A-modified ASCs would serve as a promising candidate for bettering bone defect repair.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Liu, Xiangwei& Tan, Naiwen& Zhou, Yuchao& Zhou, Xue-Ying& Chen, Hui& Wei, Hongbo…[et al.]. 2016. Semaphorin 3A Shifts Adipose Mesenchymal Stem Cells towards Osteogenic Phenotype and Promotes Bone Regeneration In Vivo. Stem Cells International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116247
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Liu, Xiangwei…[et al.]. Semaphorin 3A Shifts Adipose Mesenchymal Stem Cells towards Osteogenic Phenotype and Promotes Bone Regeneration In Vivo. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1116247
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Liu, Xiangwei& Tan, Naiwen& Zhou, Yuchao& Zhou, Xue-Ying& Chen, Hui& Wei, Hongbo…[et al.]. Semaphorin 3A Shifts Adipose Mesenchymal Stem Cells towards Osteogenic Phenotype and Promotes Bone Regeneration In Vivo. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116247
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116247
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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