Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells Derived from Human Arteries: A Novel Strategy to Accelerate Vascular Ulcer Wound Healing
المؤلفون المشاركون
Stella, Andrea
Valente, Sabrina
Ciavarella, Carmen
Pasanisi, Emanuela
Ricci, Francesca
Pasquinelli, Gianandrea
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-14
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Vascular ulcers are a serious complication of peripheral vascular disease, especially in diabetics.
Several approaches to treat the wounds are proposed but they show poor outcomes and require long healing times.
Hepatocyte Growth Factor/Scatter Factor (HGF/SF) is a pleiotropic cytokine exerting many biological activities through the c-Met receptor.
This study was aimed at verifying whether HGF/SF influences proliferation, migration, and angiogenesis on mesenchymal stem cells isolated from human arteries (hVW-MSCs).
hVW-MSCs were exposed to NIBSC HGF/SF (2.5, 5, 10, and 70 ng/mL) from 6 hrs to 7 days.
HGF and c-MET mRNA and protein expression, cell proliferation (Alamar Blue and Ki–67 assay), migration (scratch and transwell assays), and angiogenesis (Matrigel) were investigated.
hVW-MSCs displayed stemness features and expressed HGF and c-MET.
HGF/SF did not increase hVW-MSC proliferation, whereas it enhanced the cell migration, the formation of capillary-like structures, and the expression of angiogenic markers (vWF, CD31, and KDR).
The HGF/SF effects on hVW-MSC migration and angiogenic potential are of great interest to accelerate wound healing process.
Local delivery of HGF/SF could therefore improve the healing of unresponsive vascular ulcers.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Valente, Sabrina& Ciavarella, Carmen& Pasanisi, Emanuela& Ricci, Francesca& Stella, Andrea& Pasquinelli, Gianandrea. 2015. Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells Derived from Human Arteries: A Novel Strategy to Accelerate Vascular Ulcer Wound Healing. Stem Cells International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116369
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Valente, Sabrina…[et al.]. Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells Derived from Human Arteries: A Novel Strategy to Accelerate Vascular Ulcer Wound Healing. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1116369
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Valente, Sabrina& Ciavarella, Carmen& Pasanisi, Emanuela& Ricci, Francesca& Stella, Andrea& Pasquinelli, Gianandrea. Hepatocyte Growth Factor Effects on Mesenchymal Stem Cells Derived from Human Arteries: A Novel Strategy to Accelerate Vascular Ulcer Wound Healing. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116369
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116369
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر