Engineering Tendon: Scaffolds, Bioreactors, and Models of Regeneration
المؤلفون المشاركون
Youngstrom, Daniel W.
Barrett, Jennifer G.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-28
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Tendons bridge muscle and bone, translating forces to the skeleton and increasing the safety and efficiency of locomotion.
When tendons fail or degenerate, there are no effective pharmacological interventions.
The lack of available options to treat damaged tendons has created a need to better understand and improve the repair process, particularly when suitable autologous donor tissue is unavailable for transplantation.
Cells within tendon dynamically react to loading conditions and undergo phenotypic changes in response to mechanobiological stimuli.
Tenocytes respond to ultrastructural topography and mechanical deformation via a complex set of behaviors involving force-sensitive membrane receptor activity, changes in cytoskeletal contractility, and transcriptional regulation.
Effective ex vivo model systems are needed to emulate the native environment of a tissue and to translate cell-matrix forces with high fidelity.
While early bioreactor designs have greatly expanded our knowledge of mechanotransduction, traditional scaffolds do not fully model the topography, composition, and mechanical properties of native tendon.
Decellularized tendon is an ideal scaffold for cultivating replacement tissue and modeling tendon regeneration.
Decellularized tendon scaffolds (DTS) possess high clinical relevance, faithfully translate forces to the cellular scale, and have bulk material properties that match natural tissue.
This review summarizes progress in tendon tissue engineering, with a focus on DTS and bioreactor systems.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Youngstrom, Daniel W.& Barrett, Jennifer G.. 2015. Engineering Tendon: Scaffolds, Bioreactors, and Models of Regeneration. Stem Cells International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116458
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Youngstrom, Daniel W.& Barrett, Jennifer G.. Engineering Tendon: Scaffolds, Bioreactors, and Models of Regeneration. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1116458
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Youngstrom, Daniel W.& Barrett, Jennifer G.. Engineering Tendon: Scaffolds, Bioreactors, and Models of Regeneration. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116458
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116458
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر