Aggressiveness Niche: Can It Be the Foster Ground for Cancer Metastasis Precursors?
المؤلفون المشاركون
ElShamy, Wael M.
Sinha, Abhilasha
Said, Neveen
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-07-14
دولة النشر
مصر
عدد الصفحات
7
الملخص EN
The relationship between tumor initiation and tumor progression can follow a linear projection in which all tumor cells are equally endowed with the ability to progress into metastasis.
Alternatively, not all tumor cells are equal genetically and/or epigenetically, and only few cells are induced to become metastatic tumor cells.
The location of these cells within the tumor can also impact the fate of these cells.
The most inner core of a tumor where an elevated pressure of adverse conditions forms, such as necrosis-induced inflammation and hypoxia-induced immunosuppressive environment, seems to be the most fertile ground to generate such tumor cells with metastatic potential.
Here we will call this necrotic/hypoxic core the “aggressiveness niche” and will present data to support its involvement in generating these metastatic precursors.
Within this niche, interaction of hypoxia-surviving cells with the inflammatory microenvironment influenced by newly recruited mesenchymal stromal cells (MSCs), tumor-associated macrophages (TAMs), and other types of cells and the establishment of bidirectional interactions between them elevate the aggressiveness of these tumor cells.
Additionally, immune evasion properties induced in these cells most likely contribute in the formation and maintenance of such aggressiveness niche.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
ElShamy, Wael M.& Sinha, Abhilasha& Said, Neveen. 2016. Aggressiveness Niche: Can It Be the Foster Ground for Cancer Metastasis Precursors?. Stem Cells International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1116648
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
ElShamy, Wael M.…[et al.]. Aggressiveness Niche: Can It Be the Foster Ground for Cancer Metastasis Precursors?. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1116648
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
ElShamy, Wael M.& Sinha, Abhilasha& Said, Neveen. Aggressiveness Niche: Can It Be the Foster Ground for Cancer Metastasis Precursors?. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1116648
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116648
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر