Human iPSC for Therapeutic Approaches to the Nervous System: Present and Future Applications
المؤلفون المشاركون
Mastronuzzi, Angela
Carai, Andrea
Po, Agnese
Ferretti, Elisabetta
Cefalo, Maria Giuseppina
Germano, Isabelle M.
Miele, E.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-11، 11ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-30
دولة النشر
مصر
عدد الصفحات
11
الملخص EN
Many central nervous system (CNS) diseases including stroke, spinal cord injury (SCI), and brain tumors are a significant cause of worldwide morbidity/mortality and yet do not have satisfying treatments.
Cell-based therapy to restore lost function or to carry new therapeutic genes is a promising new therapeutic approach, particularly after human iPSCs became available.
However, efficient generation of footprint-free and xeno-free human iPSC is a prerequisite for their clinical use.
In this paper, we will first summarize the current methodology to obtain footprint- and xeno-free human iPSC.
We will then review the current iPSC applications in therapeutic approaches for CNS regeneration and their use as vectors to carry proapoptotic genes for brain tumors and review their applications for modelling of neurological diseases and formulating new therapeutic approaches.
Available results will be summarized and compared.
Finally, we will discuss current limitations precluding iPSC from being used on large scale for clinical applications and provide an overview of future areas of improvement.
In conclusion, significant progress has occurred in deriving iPSC suitable for clinical use in the field of neurological diseases.
Current efforts to overcome technical challenges, including reducing labour and cost, will hopefully expedite the integration of this technology in the clinical setting.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Cefalo, Maria Giuseppina& Carai, Andrea& Miele, E.& Po, Agnese& Ferretti, Elisabetta& Mastronuzzi, Angela…[et al.]. 2015. Human iPSC for Therapeutic Approaches to the Nervous System: Present and Future Applications. Stem Cells International،Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116665
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Cefalo, Maria Giuseppina…[et al.]. Human iPSC for Therapeutic Approaches to the Nervous System: Present and Future Applications. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-11.
https://search.emarefa.net/detail/BIM-1116665
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Cefalo, Maria Giuseppina& Carai, Andrea& Miele, E.& Po, Agnese& Ferretti, Elisabetta& Mastronuzzi, Angela…[et al.]. Human iPSC for Therapeutic Approaches to the Nervous System: Present and Future Applications. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-11.
https://search.emarefa.net/detail/BIM-1116665
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116665
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر