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Novel Action of FSH on Stem Cells in Adult Mammalian Ovary Induces Postnatal Oogenesis and Primordial Follicle Assembly
المؤلفون المشاركون
Sriraman, Kalpana
Parte, Seema
Patel, Hiren
Zaveri, Kusum
Hinduja, Indira
Bhartiya, Deepa
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-13، 13ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-09
دولة النشر
مصر
عدد الصفحات
13
الملخص EN
Adult mammalian ovary has been under the scanner for more than a decade now since it was proposed to harbor stem cells that undergo postnatal oogenesis during reproductive period like spermatogenesis in testis.
Stem cells are located in the ovary surface epithelium and exist in adult and menopausal ovary as well as in ovary with premature failure.
Stem cells comprise two distinct populations including spherical, very small embryonic-like stem cells (VSELs which express nuclear OCT-4 and other pluripotent and primordial germ cells specific markers) and slightly bigger ovarian germ stem cells (OGSCs with cytoplasmic OCT-4 which are equivalent to spermatogonial stem cells in the testes).
These stem cells have the ability to spontaneously differentiate into oocyte-like structures in vitro and on exposure to a younger healthy niche.
Bone marrow may be an alternative source of these stem cells.
The stem cells express FSHR and respond to FSH by undergoing self-renewal, clonal expansion, and initiating neo-oogenesis and primordial follicle assembly.
VSELs are relatively quiescent and were recently reported to survive chemotherapy and initiate oogenesis in mice when exposed to FSH.
This emerging understanding and further research in the field will help evolving novel strategies to manage ovarian pathologies and also towards oncofertility.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Bhartiya, Deepa& Parte, Seema& Patel, Hiren& Sriraman, Kalpana& Zaveri, Kusum& Hinduja, Indira. 2015. Novel Action of FSH on Stem Cells in Adult Mammalian Ovary Induces Postnatal Oogenesis and Primordial Follicle Assembly. Stem Cells International،Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116696
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Bhartiya, Deepa…[et al.]. Novel Action of FSH on Stem Cells in Adult Mammalian Ovary Induces Postnatal Oogenesis and Primordial Follicle Assembly. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-13.
https://search.emarefa.net/detail/BIM-1116696
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Bhartiya, Deepa& Parte, Seema& Patel, Hiren& Sriraman, Kalpana& Zaveri, Kusum& Hinduja, Indira. Novel Action of FSH on Stem Cells in Adult Mammalian Ovary Induces Postnatal Oogenesis and Primordial Follicle Assembly. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-13.
https://search.emarefa.net/detail/BIM-1116696
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116696
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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