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Bone Anabolic Effects of Soluble Si: In Vitro Studies with Human Mesenchymal Stem Cells and CD14+ Osteoclast Precursors
المؤلفون المشاركون
Fernandes, Maria Helena
Costa-Rodrigues, J.
Reis, S.
Castro, A.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-12، 12ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-20
دولة النشر
مصر
عدد الصفحات
12
الملخص EN
Silicon (Si) is indispensable for many cellular processes including bone tissue metabolism.
In this work, the effects of Si on human osteogenesis and osteoclastogenesis were characterized.
Human mesenchymal stem cells (hMSC) and CD14+ stem cells, as osteoblast and osteoclast precursors, were treated with a wide range of Si concentrations, covering the physiological plasma levels.
Si promoted a dose-dependent increase in hMSC proliferation, differentiation, and function, at levels similar to the normal basal plasma levels.
Additionally, a decrease in the expression of the osteoclastogenic activators M-CSF and RANKL was observed.
Also, Si elicited a decrease in osteoclastogenesis, which became significant at higher concentrations, as those observed after meals.
Among the intracellular mechanisms studied, an upregulation of MEK and PKC signalling pathways was observed in both cell types.
In conclusion, Si appears to have a direct positive effect on human osteogenesis, at basal plasma levels.
On the other hand, it also seemed to be an inhibitor of osteoclastogenesis, but at higher concentrations, though yet in the physiological range.
Further, an indirect effect of Si on osteoclastogenesis may also occur, through a downregulation of M-CSF and RANKL expression by osteoblasts.
Thus, Si may be an important player in bone anabolic regenerative approaches.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Costa-Rodrigues, J.& Reis, S.& Castro, A.& Fernandes, Maria Helena. 2015. Bone Anabolic Effects of Soluble Si: In Vitro Studies with Human Mesenchymal Stem Cells and CD14+ Osteoclast Precursors. Stem Cells International،Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1116785
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Costa-Rodrigues, J.…[et al.]. Bone Anabolic Effects of Soluble Si: In Vitro Studies with Human Mesenchymal Stem Cells and CD14+ Osteoclast Precursors. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-12.
https://search.emarefa.net/detail/BIM-1116785
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Costa-Rodrigues, J.& Reis, S.& Castro, A.& Fernandes, Maria Helena. Bone Anabolic Effects of Soluble Si: In Vitro Studies with Human Mesenchymal Stem Cells and CD14+ Osteoclast Precursors. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-12.
https://search.emarefa.net/detail/BIM-1116785
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116785
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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