Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche
المؤلفون المشاركون
Lafourcade, Carlos
Wyneken, Ursula
Luarte, Alejandro
Bátiz, Luis Federico
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-04-19
دولة النشر
مصر
عدد الصفحات
16
الملخص EN
Neurodegenerative disorders are one of the leading causes of death and disability and one of the biggest burdens on health care systems.
Novel approaches using various types of stem cells have been proposed to treat common neurodegenerative disorders such as Alzheimer’s Disease, Parkinson’s Disease, or stroke.
Moreover, as the secretome of these cells appears to be of greater benefit compared to the cells themselves, the extracellular components responsible for its therapeutic benefit have been explored.
Stem cells, as well as most cells, release extracellular vesicles such as exosomes, which are nanovesicles able to target specific cell types and thus to modify their function by delivering proteins, lipids, and nucleic acids.
Exosomes have recently been tested in vivo and in vitro as therapeutic conveyors for the treatment of diseases.
As such, they could be engineered to target specific populations of cells within the CNS.
Considering the fact that many degenerative brain diseases have an impact on adult neurogenesis, we discuss how the modulation of the adult neurogenic niches may be a therapeutic target of stem cell-derived exosomes.
These novel approaches should be examined in cellular and animal models to provide better, more effective, and specific therapeutic tools in the future.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Luarte, Alejandro& Bátiz, Luis Federico& Wyneken, Ursula& Lafourcade, Carlos. 2016. Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche. Stem Cells International،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1116813
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Luarte, Alejandro…[et al.]. Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1116813
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Luarte, Alejandro& Bátiz, Luis Federico& Wyneken, Ursula& Lafourcade, Carlos. Potential Therapies by Stem Cell-Derived Exosomes in CNS Diseases: Focusing on the Neurogenic Niche. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1116813
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116813
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر