Allogeneic Mesenchymal Stem Cell Treatment Induces Specific Alloantibodies in Horses
المؤلفون المشاركون
Kol, Amir
Walker, Naomi J.
Borjesson, Dori L.
Owens, Sean D.
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-28
دولة النشر
مصر
عدد الصفحات
8
الملخص EN
Background.
It is unknown whether horses that receive allogeneic mesenchymal stem cells (MSCs) injections develop specific humoral immune response.
Our goal was to develop and validate a flow cytometric MSC crossmatch procedure and to determine if horses that received allogeneic MSCs in a clinical setting developed measurable antibodies following MSC administration.
Methods.
Serum was collected from a total of 19 horses enrolled in 3 different research projects.
Horses in the 3 studies all received unmatched allogeneic MSCs.
Bone marrow (BM) or adipose tissue derived MSCs (ad-MSCs) were administered via intravenous, intra-arterial, intratendon, or intraocular routes.
Anti-MSCs and anti-bovine serum albumin antibodies were detected via flow cytometry and ELISA, respectively.
Results.
Overall, anti-MSC antibodies were detected in 37% of the horses.
The majority of horses (89%) were positive for anti-bovine serum albumin (BSA) antibodies prior to and after MSC injection.
Finally, there was no correlation between the amount of anti-BSA antibody and the development of anti-MSC antibodies.
Conclusion.
Anti allo-MSC antibody development was common; however, the significance of these antibodies is unknown.
There was no correlation between either the presence or absence of antibodies and the percent antibody binding to MSCs and any adverse reaction to a MSC injection.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Owens, Sean D.& Kol, Amir& Walker, Naomi J.& Borjesson, Dori L.. 2016. Allogeneic Mesenchymal Stem Cell Treatment Induces Specific Alloantibodies in Horses. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116837
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Owens, Sean D.…[et al.]. Allogeneic Mesenchymal Stem Cell Treatment Induces Specific Alloantibodies in Horses. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1116837
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Owens, Sean D.& Kol, Amir& Walker, Naomi J.& Borjesson, Dori L.. Allogeneic Mesenchymal Stem Cell Treatment Induces Specific Alloantibodies in Horses. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116837
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116837
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر