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Ciprofloxacin Improves the Stemness of Human Dermal Papilla Cells
المؤلفون المشاركون
Chanvorachote, Pithi
Kiratipaiboon, Chayanin
Tengamnuay, Parkpoom
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-14، 14ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-16
دولة النشر
مصر
عدد الصفحات
14
الملخص EN
Improvement in the expansion method of adult stem cells may augment their use in regenerative therapy.
Using human dermal papilla cell line as well as primary dermal papilla cells as model systems, the present study demonstrated that ciprofloxacin treatment could prevent the loss of stemness during culture.
Clonogenicity and stem cell markers of dermal papilla cells were shown to gradually decrease in the culture in a time-dependent manner.
Treatment of the cells with nontoxic concentrations of ciprofloxacin could maintain both stem cell morphology and clonogenicity, as well as all stem cells markers.
We found that ciprofloxacin exerted its effect through ATP-dependent tyrosine kinase/glycogen synthase kinase3β dependent mechanism which in turn upregulated β-catenin.
Besides, ciprofloxacin was shown to induce epithelial-mesenchymal transition in DPCs as the transcription factors ZEB1 and Snail were significantly increased.
Furthermore, the self-renewal proteins of Wnt/β-catenin pathway, namely, Nanog and Oct-4 were significantly upregulated in the ciprofloxacin-treated cells.
The effects of ciprofloxacin in preserving stem cell features were confirmed in the primary dermal papilla cells directly obtained from human hair follicles.
Together, these results revealed a novel application of ciprofloxacin for stem cell maintenance and provided the underlying mechanisms that are responsible for the stemness in dermal papilla cells.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Kiratipaiboon, Chayanin& Tengamnuay, Parkpoom& Chanvorachote, Pithi. 2015. Ciprofloxacin Improves the Stemness of Human Dermal Papilla Cells. Stem Cells International،Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1116839
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Kiratipaiboon, Chayanin…[et al.]. Ciprofloxacin Improves the Stemness of Human Dermal Papilla Cells. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-14.
https://search.emarefa.net/detail/BIM-1116839
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Kiratipaiboon, Chayanin& Tengamnuay, Parkpoom& Chanvorachote, Pithi. Ciprofloxacin Improves the Stemness of Human Dermal Papilla Cells. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-14.
https://search.emarefa.net/detail/BIM-1116839
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116839
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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