Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia
المؤلفون المشاركون
Chen, Lukui
Zhang, Guilong
Khan, Ahsan Ali
Guo, Xiaoyuan
Gu, Yuchun
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-8، 8ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-08-31
دولة النشر
مصر
عدد الصفحات
8
الملخص EN
Objective.
Systematic review and meta-analysis to observe the efficacy and safety of stem cell transplantation therapy in patients with brain ischemia.
Methods.
We searched Cochrane Library, PubMed, Ovid, CBM, CNKI, WanFang, and VIP Data from its inception to December 2015, to collect randomized controlled trials (RCT) of stem cell transplantation for the ischemic stroke.
Two authors independently screened the literature according to the inclusion and exclusion criteria, extracted data, and assessed the risk of bias.
Thereafter, meta-analysis was performed.
Results.
Sixteen studies and eighteen independent treatments were included in the current meta-analysis.
The results based upon the pooled mean difference from baseline to follow-up points showed that the stem cell transplantation group was superior to the control group with statistical significance in the neurologic deficits score (NIHSS, MD = 1.57; 95% CI, 0.64–2.51; I 2 = 57 %; p = 0.001 ), motor function (FMA, MD = 4.23; 95% CI, 3.08–5.38; I 2 = 0 %; p < 0.00001 ), daily life ability (Barthel, MD = 8.37; 95% CI, 4.83–11.91; I 2 = 63 %; p < 0.00001 ), and functional independence (FIM, MD = 8.89; 95% CI, 4.70–13.08; I 2 = 79 %; p < 0.0001 ).
Conclusions.
It is suggested that the stem cell transplantation therapy for patients with brain ischemic stroke can significantly improve the neurological deficits and daily life quality, with no serious adverse events.
However, higher quality and larger data studies are required for further investigation to support clinical application of stem cell transplantation.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Chen, Lukui& Zhang, Guilong& Khan, Ahsan Ali& Guo, Xiaoyuan& Gu, Yuchun. 2016. Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia. Stem Cells International،Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116873
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Chen, Lukui…[et al.]. Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-8.
https://search.emarefa.net/detail/BIM-1116873
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Chen, Lukui& Zhang, Guilong& Khan, Ahsan Ali& Guo, Xiaoyuan& Gu, Yuchun. Clinical Efficacy and Meta-Analysis of Stem Cell Therapies for Patients with Brain Ischemia. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-8.
https://search.emarefa.net/detail/BIM-1116873
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116873
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر