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Phase III Trial of Autologous Bone Marrow Stem Cell Transplantation with a Three-Dimensional Woven-Fabric Scaffold for Periodontitis
المؤلفون المشاركون
Umeda, Makoto
Baba, Shunsuke
Yamada, Yoichi
Komuro, Akira
Yotsui, Yoritaka
Shimuzutani, Kimishige
Nakamura, Sayaka
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-11-20
دولة النشر
مصر
عدد الصفحات
7
الملخص EN
Regenerative medicine is emerging as a promising option, but the potential of autologous stem cells has not been investigated well in clinical settings of periodontal treatment.
In this clinical study, we evaluated the safety and efficacy of a new regenerative therapy based on the surgical implantation of autologous mesenchymal stem cells (MSCs) with a biodegradable three-dimensional (3D) woven-fabric composite scaffold and platelet-rich plasma (PRP).
Ten patients with periodontitis, who required a surgical procedure for intrabony defects, were enrolled in phase I/II trial.
Once MSCs were implanted in each periodontal intrabony defect, the patients were monitored during 36 months for a medical exam including laboratory tests of blood and urine samples, changes in clinical attachment level, pocket depth, and linear bone growth (LBG).
All three parameters improved significantly during the entire follow-up period (p<0.0001), leading to an average LBG of 4.7 mm after 36 months.
Clinical mobility measured by Periotest showed a decreasing trend after the surgery.
No clinical safety problems attributable to the investigational MSCs were identified.
This clinical trial suggests that the stem cell therapy using MSCs-PRP/3D woven-fabric composite scaffold may constitute a novel safe and effective regenerative treatment option for periodontitis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Baba, Shunsuke& Yamada, Yoichi& Komuro, Akira& Yotsui, Yoritaka& Umeda, Makoto& Shimuzutani, Kimishige…[et al.]. 2016. Phase III Trial of Autologous Bone Marrow Stem Cell Transplantation with a Three-Dimensional Woven-Fabric Scaffold for Periodontitis. Stem Cells International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1116896
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Baba, Shunsuke…[et al.]. Phase III Trial of Autologous Bone Marrow Stem Cell Transplantation with a Three-Dimensional Woven-Fabric Scaffold for Periodontitis. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1116896
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Baba, Shunsuke& Yamada, Yoichi& Komuro, Akira& Yotsui, Yoritaka& Umeda, Makoto& Shimuzutani, Kimishige…[et al.]. Phase III Trial of Autologous Bone Marrow Stem Cell Transplantation with a Three-Dimensional Woven-Fabric Scaffold for Periodontitis. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1116896
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116896
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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