The Characteristics Variation of Hepatic Progenitors after TGF-β1-Induced Transition and EGF-Induced Reversion
المؤلفون المشاركون
Wang, Ping
Cong, Min
Liu, Tian-Hui
Jia, Ji-Dong
You, Hong
Yang, Aiting
Sun, Guangyong
Zhang, Dong
Huang, Jian
Sun, Shujie
Mao, Jia
Ma, Hong
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-02-03
دولة النشر
مصر
عدد الصفحات
10
الملخص EN
Profibrogenesis cytokine, transforming growth factor- (TGF-) β1, induces hepatic progenitors experiencing epithelial to mesenchymal transition (EMT) to matrix synthesis cells, even tumor initiating cells.
Our previous data found that epidermal growth factor (EGF) blocks and reverses TGF-β1-induced transition.
The aim of this study is to determine the characteristic changes of hepatic progenitors after TGF-β1-induced transition and EGF-induced reversion.
Hepatic oval cells, rat hepatic progenitors, were isolated from rats fed a choline-deficient diet supplemented with ethionine.
TGF-β1-containing medium was used for inducing EMT, while EGF-containing medium was used for reversing EMT.
During TGF-β1-induced transition and EGF-induced reversion, hepatic oval cells sustained their progenitor cell marker expression, including α-fetoprotein, albumin, and cytokeratin-19.
The proliferation ability and differentiation potential of these cells were suppressed by TGF-β1, while EGF resumed these capacities to the level similar to the control cells.
RNA microarray analysis showed that most of the genes with significant changes after TGF-β1 incubation were recovered by EGF.
Signal pathway analysis revealed that TGF-β1 impaired the pathways of cell cycle and cytochrome P450 detoxification, and EGF reverted TGF-β1 effects through activating MAPK and PI3K-Akt pathway.
EGF reverses the characteristics impaired by TGF-β1 in hepatic oval cells, serving as a protective cytokine to hepatic progenitors.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Wang, Ping& Cong, Min& Liu, Tian-Hui& Yang, Aiting& Sun, Guangyong& Zhang, Dong…[et al.]. 2016. The Characteristics Variation of Hepatic Progenitors after TGF-β1-Induced Transition and EGF-Induced Reversion. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116909
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Wang, Ping…[et al.]. The Characteristics Variation of Hepatic Progenitors after TGF-β1-Induced Transition and EGF-Induced Reversion. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1116909
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Wang, Ping& Cong, Min& Liu, Tian-Hui& Yang, Aiting& Sun, Guangyong& Zhang, Dong…[et al.]. The Characteristics Variation of Hepatic Progenitors after TGF-β1-Induced Transition and EGF-Induced Reversion. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1116909
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116909
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر