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Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance
المؤلفون المشاركون
Benedetti, Elisabetta
Cimini, AnnaMaria
Antonosante, Andrea
Fidoamore, Alessia
Cristiano, Loredana
d’Angelo, Michele
Di Giacomo, Erica
Astarita, Carlo
Giordano, Antonio
Ippoliti, Rodolfo
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-17، 17ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2016-01-06
دولة النشر
مصر
عدد الصفحات
17
الملخص EN
Among all solid tumors, the high-grade glioma appears to be the most vascularized one.
In fact, “microvascular hyperplasia” is a hallmark of GBM.
An altered vascular network determines irregular blood flow, so that tumor cells spread rapidly beyond the diffusion distance of oxygen in the tissue, with the consequent formation of hypoxic or anoxic areas, where the bulk of glioblastoma stem cells (GSCs) reside.
The response to this event is the induction of angiogenesis, a process mediated by hypoxia inducible factors.
However, this new capillary network is not efficient in maintaining a proper oxygen supply to the tumor mass, thereby causing an oxygen gradient within the neoplastic zone.
This microenvironment helps GSCs to remain in a “quiescent” state preserving their potential to proliferate and differentiate, thus protecting them by the effects of chemo- and radiotherapy.
Recent evidences suggest that responses of glioblastoma to standard therapies are determined by the microenvironment of the niche, where the GSCs reside, allowing a variety of mechanisms that contribute to the chemo- and radioresistance, by preserving GSCs.
It is, therefore, crucial to investigate the components/factors of the niche in order to formulate new adjuvant therapies rendering more efficiently the gold standard therapies for this neoplasm.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Fidoamore, Alessia& Cristiano, Loredana& Antonosante, Andrea& d’Angelo, Michele& Di Giacomo, Erica& Astarita, Carlo…[et al.]. 2016. Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance. Stem Cells International،Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1116971
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Fidoamore, Alessia…[et al.]. Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-17.
https://search.emarefa.net/detail/BIM-1116971
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Fidoamore, Alessia& Cristiano, Loredana& Antonosante, Andrea& d’Angelo, Michele& Di Giacomo, Erica& Astarita, Carlo…[et al.]. Glioblastoma Stem Cells Microenvironment: The Paracrine Roles of the Niche in Drug and Radioresistance. Stem Cells International. 2016. Vol. 2016, no. 2016, pp.1-17.
https://search.emarefa.net/detail/BIM-1116971
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1116971
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر
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