Androgen Modulates Functions of Endothelial Progenitor Cells through Activated Egr1 Signaling
المؤلفون المشاركون
Yang, Junjie
Ye, Yizhou
Li, Xizhe
Zhang, You
Shen, Zhenya
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-16، 16ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-11-30
دولة النشر
مصر
عدد الصفحات
16
الملخص EN
Researches show that androgens have important effects on migration of endothelial cells and endothelial protection in coronary heart disease.
Endothelial progenitor cells (EPCs) as a progenitor cell type that can differentiate into endothelial cells, have a critical role in angiogenesis and endothelial protection.
The relationship between androgen and the functions of EPCs has animated much interest and controversy.
In this study, we investigated the angiogenic and migratory functions of EPCs after treatment by dihydrotestosterone (DHT) and the molecular mechanisms as well.
We found that DHT treatment enhanced the incorporation of EPCs into tubular structures formed by HUVECs and the migratory activity of EPCs in the transwell assay dose dependently.
Moreover, microarray analysis was performed to explore how DHT changes the gene expression profiles of EPCs.
We found 346 differentially expressed genes in androgen-treated EPCs.
Angiogenesis-related genes like Egr-1, Vcan, Efnb2, and Cdk2ap1 were identified to be regulated upon DHT treatment.
Furthermore, the enhanced angiogenic and migratory abilities of EPCs after DHT treatment were inhibited by Egr1-siRNA transfection.
In conclusion, our findings suggest that DHT markedly enhances the vessel forming ability and migration capacity of EPCs.
Egr1 signaling may be a possible pathway in this process.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ye, Yizhou& Li, Xizhe& Zhang, You& Shen, Zhenya& Yang, Junjie. 2015. Androgen Modulates Functions of Endothelial Progenitor Cells through Activated Egr1 Signaling. Stem Cells International،Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1117029
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ye, Yizhou…[et al.]. Androgen Modulates Functions of Endothelial Progenitor Cells through Activated Egr1 Signaling. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-16.
https://search.emarefa.net/detail/BIM-1117029
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ye, Yizhou& Li, Xizhe& Zhang, You& Shen, Zhenya& Yang, Junjie. Androgen Modulates Functions of Endothelial Progenitor Cells through Activated Egr1 Signaling. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-16.
https://search.emarefa.net/detail/BIM-1117029
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117029
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر