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Peripheral Blood Monocytes as Adult Stem Cells: Molecular Characterization and Improvements in Culture Conditions to Enhance Stem Cell Features and Proliferative Potential
المؤلفون المشاركون
Grage-Griebenow, Evelin
Nussler, Andreas K.
Ungefroren, Hendrik
Hyder, Ayman
Schulze, Maren
Fawzy El-Sayed, Karim M.
Fändrich, Fred
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-7، 7ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-20
دولة النشر
مصر
عدد الصفحات
7
الملخص EN
Adult stem or programmable cells hold great promise in diseases in which damaged or nonfunctional cells need to be replaced.
We have recently demonstrated that peripheral blood monocytes can be differentiated in vitro into cells resembling specialized cell types like hepatocytes and pancreatic beta cells.
During phenotypic conversion, the monocytes downregulate monocyte/macrophage differentiation markers, being indicative of partial dedifferentiation, and are partially reprogrammed to acquire a state of plasticity along with expression of various markers of pluripotency and resumption of mitosis.
Upregulation of stem cell markers and mitotic activity in the cultures was shown to be controlled by autocrine production/secretion of activin A and transforming growth factor-beta (TGF-β).
These reprogrammed monocyte derivatives were termed “programmable cells of monocytic origin” (PCMO).
Current efforts focus on establishing culture conditions that increase both the plasticity and proliferation potential of PCMO in order to be able to generate large amounts of blood-derived cells suitable for both autologous and allogeneic therapies.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Ungefroren, Hendrik& Hyder, Ayman& Schulze, Maren& Fawzy El-Sayed, Karim M.& Grage-Griebenow, Evelin& Nussler, Andreas K.…[et al.]. 2015. Peripheral Blood Monocytes as Adult Stem Cells: Molecular Characterization and Improvements in Culture Conditions to Enhance Stem Cell Features and Proliferative Potential. Stem Cells International،Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1117046
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Ungefroren, Hendrik…[et al.]. Peripheral Blood Monocytes as Adult Stem Cells: Molecular Characterization and Improvements in Culture Conditions to Enhance Stem Cell Features and Proliferative Potential. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-7.
https://search.emarefa.net/detail/BIM-1117046
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Ungefroren, Hendrik& Hyder, Ayman& Schulze, Maren& Fawzy El-Sayed, Karim M.& Grage-Griebenow, Evelin& Nussler, Andreas K.…[et al.]. Peripheral Blood Monocytes as Adult Stem Cells: Molecular Characterization and Improvements in Culture Conditions to Enhance Stem Cell Features and Proliferative Potential. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-7.
https://search.emarefa.net/detail/BIM-1117046
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117046
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
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