The Fate and Distribution of Autologous Bone Marrow Mesenchymal Stem Cells with Intra-Arterial Infusion in Osteonecrosis of the Femoral Head in Dogs
المؤلفون المشاركون
Jin, Hongting
Xu, Taotao
Chen, Qiqing
Wu, Chengliang
Wang, Pinger
Mao, Qiang
Zhang, Shanxing
Shen, Jiayi
Tong, Peijian
المصدر
العدد
المجلد 2016، العدد 2016 (31 ديسمبر/كانون الأول 2015)، ص ص. 1-10، 10ص.
الناشر
Hindawi Publishing Corporation
تاريخ النشر
2015-12-08
دولة النشر
مصر
عدد الصفحات
10
الملخص EN
This study aimed to investigate if autologous bone marrow mesenchymal stem cells (MSCs) could treat osteonecrosis of the femoral head (ONFH) and what the fate and distribution of the cells are in dogs.
Twelve Beagle dogs were randomly divided into two groups: MSCs group and SHAM operated group.
After three weeks, dogs in MSCs group and SHAM operated group were intra-arterially injected with autologous MSCs and 0.9% normal saline, respectively.
Eight weeks after treatment, the necrotic volume of the femoral heads was significantly reduced in MSCs group.
Moreover, the trabecular bone volume was increased and the empty lacunae rate was decreased in MSCs group.
In addition, the BrdU-positive MSCs were unevenly distributed in femoral heads and various vital organs.
But no obvious abnormalities were observed.
Furthermore, most of BrdU-positive MSCs in necrotic region expressed osteocalcin in MSCs group and a few expressed peroxisome proliferator-activated receptor-γ (PPAR-γ).
Taken together, these data indicated that intra-arterially infused MSCs could migrate into the necrotic field of femoral heads and differentiate into osteoblasts, thus improving the necrosis of femoral heads.
It suggests that intra-arterial infusion of autologous MSCs might be a feasible and relatively safe method for the treatment of femoral head necrosis.
نمط استشهاد جمعية علماء النفس الأمريكية (APA)
Jin, Hongting& Xu, Taotao& Chen, Qiqing& Wu, Chengliang& Wang, Pinger& Mao, Qiang…[et al.]. 2015. The Fate and Distribution of Autologous Bone Marrow Mesenchymal Stem Cells with Intra-Arterial Infusion in Osteonecrosis of the Femoral Head in Dogs. Stem Cells International،Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117296
نمط استشهاد الجمعية الأمريكية للغات الحديثة (MLA)
Jin, Hongting…[et al.]. The Fate and Distribution of Autologous Bone Marrow Mesenchymal Stem Cells with Intra-Arterial Infusion in Osteonecrosis of the Femoral Head in Dogs. Stem Cells International Vol. 2016, no. 2016 (2015), pp.1-10.
https://search.emarefa.net/detail/BIM-1117296
نمط استشهاد الجمعية الطبية الأمريكية (AMA)
Jin, Hongting& Xu, Taotao& Chen, Qiqing& Wu, Chengliang& Wang, Pinger& Mao, Qiang…[et al.]. The Fate and Distribution of Autologous Bone Marrow Mesenchymal Stem Cells with Intra-Arterial Infusion in Osteonecrosis of the Femoral Head in Dogs. Stem Cells International. 2015. Vol. 2016, no. 2016, pp.1-10.
https://search.emarefa.net/detail/BIM-1117296
نوع البيانات
مقالات
لغة النص
الإنجليزية
الملاحظات
Includes bibliographical references
رقم السجل
BIM-1117296
قاعدة معامل التأثير والاستشهادات المرجعية العربي "ارسيف Arcif"
أضخم قاعدة بيانات عربية للاستشهادات المرجعية للمجلات العلمية المحكمة الصادرة في العالم العربي
تقوم هذه الخدمة بالتحقق من التشابه أو الانتحال في الأبحاث والمقالات العلمية والأطروحات الجامعية والكتب والأبحاث باللغة العربية، وتحديد درجة التشابه أو أصالة الأعمال البحثية وحماية ملكيتها الفكرية. تعرف اكثر